Atopic dermatitis epidemiology and unmet need in the United Kingdom.
Atopic dermatitis epidemiology and unmet need in the United Kingdom.
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DOI：
10.1080/09546634.2019.1655137
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Ogg GS
中科院分区：
文献类型：
--
作者：
Cork MJ;Danby SG;Ogg GS
特应性皮炎(AD)，又称特应性湿疹，是一种慢性炎症性皮肤疾病，与重大的健康和社会经济负担有关，其特征是剧烈瘙痒，皮肤屏障破坏，2型介导的免疫反应上调。在英国，阿尔茨海默病的发病率很高，影响到11%-20%的儿童和5%-10%的成年人。在英国，大约2%的儿童AD病例是严重的。尽管如此，大多数AD治疗都是在家里进行的，很少与医疗保健提供者或服务机构接触。在这里，我们讨论AD的病程，治疗实践，以及英国未得到满足的需求。尽管阿尔茨海默病的潜在病因仍在研究中，但目前认为是由于皮肤屏障功能障碍和炎症反应改变所致。AD的治疗重点是避免触发因素，改善皮肤水合，管理加剧因素，并通过局部和全身免疫抑制剂减少炎症。然而，还有一个重要的未得到满足的需求，即改善AD的整体管理，并通过安全有效的治疗帮助患者控制他们的疾病。针对单个炎症途径的方法(例如，DUPILUMA、抗白细胞介素4受体α)正在出现，并可能为患者提供进一步的治疗机会。
Atopic dermatitis (AD), also known as atopic eczema, is a chronic inflammatory skin condition associated with a significant health-related and socioeconomic burden, and is characterized by intense itch, disruption of the skin barrier, and upregulation of type 2-mediated immune responses. The United Kingdom (UK) has a high prevalence of AD, affecting 11–20% of children and 5–10% of adults. Approximately 2% of all cases of childhood AD in the UK are severe. Despite this, most AD treatments are performed at home, with little contact with healthcare providers or services. Here, we discuss the course of AD, treatment practices, and unmet need in the UK. Although the underlying etiology of the disease is still emerging, AD is currently attributed to skin barrier dysfunction and altered inflammatory responses. Management of AD focuses on avoiding triggers, improving skin hydration, managing exacerbating factors, and reducing inflammation through topical and systemic immunosuppressants. However, there is a significant unmet need to improve the overall management of AD and help patients gain control of their disease through safe and effective treatments. Approaches that target individual inflammatory pathways (e.g. dupilumab, anti-interleukin (IL)-4 receptor α) are emerging and likely to provide further therapeutic opportunities for patient benefit.
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影响因子：
1.6
作者：
Andersen YMF;Egeberg A;Skov L;Thyssen JP
通讯作者：
Thyssen JP
影响因子：
10.3
作者：
Danby, S. G.;Al-Enezi, T.;Cork, M. J.
通讯作者：
Cork, M. J.
影响因子：
14.2
作者：
Bilsborough, J;Leung, DYM;Gross, JA
通讯作者：
Gross, JA
影响因子：
5.2
作者：
DAUD, LR;GARRALDA, ME;DAVID, TJ
通讯作者：
DAVID, TJ
影响因子：
168.9
作者：
Asher, M. Innes;Montefort, Stephen;Williams, Hywel
通讯作者：
Williams, Hywel