Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway.
Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway.
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DOI：
10.1371/journal.pone.0039061
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Platel B
中科院分区：
文献类型：
--
作者：
Brunenberg EJ;Moeskops P;Backes WH;Pollo C;Cammoun L;Vilanova A;Janssen ML;Visser-Vandewalle VE;ter Haar Romeny BM;Thiran JP;Platel B
深部脑刺激（DBS）治疗帕金森病通常会减轻运动症状，但在相当数量的病例中会引起认知和情绪副作用。作为手术前检查的一部分，识别丘脑底核（STN）的运动部分可以最大限度地减少这些不良影响。在这项研究中，我们评估了运动，联想和边缘脑区的连接，基于志愿者数据的结构和功能连接分析。对于结构连接性，我们使用来自HARDI纤维跟踪的流线计数。由此产生的轨迹支持了人类所谓的“超直接”途径的存在。此外，我们还确定了每个运动皮质区的三维体素的连通性。基于功能性MRI计算功能连接性，作为给定脑体素内的信号与脑中信号的相关性。此外，每个像素的信号与运动或边缘脑种子ROI区域的相关性进行了解释。左右两侧的脑脊膜ROI似乎在结构和功能上都与运动、联想和边缘回路的大脑区域相连。此外，这项研究使我们能够评估与DBS手术计划相关的运动神经部分的隔离水平。
Deep brain stimulation (DBS) for Parkinson’s disease often alleviates the motor symptoms, but causes cognitive and emotional side effects in a substantial number of cases. Identification of the motor part of the subthalamic nucleus (STN) as part of the presurgical workup could minimize these adverse effects. In this study, we assessed the STN’s connectivity to motor, associative, and limbic brain areas, based on structural and functional connectivity analysis of volunteer data. For the structural connectivity, we used streamline counts derived from HARDI fiber tracking. The resulting tracks supported the existence of the so-called “hyperdirect” pathway in humans. Furthermore, we determined the connectivity of each STN voxel with the motor cortical areas. Functional connectivity was calculated based on functional MRI, as the correlation of the signal within a given brain voxel with the signal in the STN. Also, the signal per STN voxel was explained in terms of the correlation with motor or limbic brain seed ROI areas. Both right and left STN ROIs appeared to be structurally and functionally connected to brain areas that are part of the motor, associative, and limbic circuit. Furthermore, this study enabled us to assess the level of segregation of the STN motor part, which is relevant for the planning of STN DBS procedures.
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影响因子：
4.1
作者：
Cho ZH;Min HK;Oh SH;Han JY;Park CW;Chi JG;Kim YB;Paek SH;Lozano AM;Lee KH
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