Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse.
Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse.
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概念化冲动性和风险服用双相情感障碍：酗酒史的重要性。
DOI：
10.1111/j.1399-5618.2008.00657.x
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发表时间：
2009-02
影响因子：
5.4
通讯作者：
Glahn DC
中科院分区：
文献类型：
--
作者：
Kathleen Holmes M;Bearden CE;Barguil M;Fonseca M;Serap Monkul E;Nery FG;Soares JC;Mintz J;Glahn DC
冲动水平升高和冒险行为增加被认为是双相情感障碍（BD）和成瘾性疾病的核心特征。鉴于双相情感障碍中酒精滥用的共病率很高，酒精成瘾可能会加剧双相情感障碍中的冲动行为和冒险倾向。在这里，我们使用认知任务和自我报告措施，检查有或没有酗酒史的 BD 患者的冲动和冒险行为的多个维度。使用 Barratt 冲动量表 (BIS) 和计算机化气球模拟风险任务 (BART) 对 31 名有酒精滥用或依赖史的 BD 受试者 (BD-A)、24 名没有酒精滥用/依赖史的 BD 受试者 (BD-N) 和 25 名健康对照受试者 (HC) 进行评估。两个 BD 组的 BIS 得分均显着高于对照组。相比之下，只有 BD-A 组的 BART 表现受损。 BD-A 组的气球比 BD-N 组和 HC 组弹出的气球要多得多。此外，BD-A组的受试者在爆破气球后未能调整自己的表现。情绪症状的严重程度与这两项任务的表现均无关。目前的研究支持先前酗酒对双相情感障碍患者的冒险倾向的主要作用。此外，研究结果表明，冲动和危险行为分别通过自我报告和实验认知探索来操作，是可分离的结构，可以利用双相情感障碍表型的不同方面。
Elevated levels of impulsivity and increased risk taking are thought to be core features of both bipolar disorder (BD) and addictive disorders. Given the high rates of comorbid alcohol abuse in BD, alcohol addiction may exacerbate impulsive behavior and risk-taking propensity in BD. Here we examine multiple dimensions of impulsivity and risk taking, using cognitive tasks and self-report measures, in BD patients with and without a history of alcohol abuse. Thirty-one BD subjects with a prior history of alcohol abuse or dependence (BD-A), 24 BD subjects with no history of alcohol abuse / dependence (BD-N), and 25 healthy control subjects (HC) were assessed with the Barratt Impulsiveness Scale (BIS) and the computerized Balloon Analogue Risk Task (BART). Both BD groups scored significantly higher than controls on the BIS. In contrast, only the BD-A group showed impaired performance on the BART. BD-A subjects popped significantly more balloons than the BD-N and HC groups. In addition, subjects in the BD-A group failed to adjust their performance after popping balloons. Severity of mood symptomatology was not associated with performance on either task. The current study supports a primary role of prior alcohol abuse in risk-taking propensity among patients with bipolar disorder. In addition, findings suggest that impulsivity and risky behavior, as operationalized by self-report and experimental cognitive probes, respectively, are separable constructs that tap distinct aspects of the bipolar phenotype.
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影响因子：
25
作者：
Kreek, MJ;Nielsen, DA;LaForge, KS
通讯作者：
LaForge, KS
影响因子：
--
作者：
Merikangas, Kathleen R.;Akiskal, Hagop S.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
影响因子：
4.4
作者：
Merikangas, KR;Mehta, RL;Kessler, RC
通讯作者：
Kessler, RC
影响因子：
17.7
作者：
Tarter, RE;Kirisci, L;Clark, D
通讯作者：
Clark, D
DOI：
10.1097/01.chi.0000188893.60551.31
发表时间：
2006-02-01
影响因子：
13.3
作者：
Crowley, TJ;Raymond, KM;Lejuez, CW
通讯作者：
Lejuez, CW