Neural regulation of the time course for cocaine-cue extinction consolidation in rats.
Neural regulation of the time course for cocaine-cue extinction consolidation in rats.
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DOI：
10.1111/ejn.12035
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Kantak KM
中科院分区：
文献类型：
--
作者：
Szalay JJ;Jordan CJ;Kantak KM
Sites within the hippocampus, amygdala and prefrontal cortex may regulate how responses maintained by cues associated with cocaine are extinguished. To test the role of various brain sites in the consolidation of cocaine-cue extinction learning, the dorsal subiculum (dSUB), rostral basolateral amygdala (rBLA) and infralimbic prefrontal cortex (IL) were manipulated in rats. Following cocaine self-administration training (cues present, cocaine available), responding was assessed during 1 hr extinction tests (cues present, no cocaine available). To study extinction consolidation specifically, the protein synthesis inhibitor anisomycin or vehicle was infused bilaterally into the dSUB, rBLA or IL either immediately following or 6 hr after the first two of three extinction training sessions. With manipulations made immediately after extinction sessions, infusions of anisomycin into the dSUB or the rBLA deterred extinction. Rats maintained elevated levels of cocaine seeking relative to vehicle despite the absence of cocaine delivery. Manipulations of IL had no effect. Control studies showed that bilateral protein synthesis inhibition in dSUB and rBLA 6 hr after the extinction sessions ended was unable to deter extinction. Rats reduced cocaine seeking in the usual manner in the absence of cocaine delivery. Collectively, these findings suggest that the dSUB and rBLA are neural substrates important for consolidation of cocaine-cue extinction learning and have time-dependent roles. Understanding the contribution of individual neural substrates for cocaine-cue extinction consolidation may help guide treatment strategies aimed at enhancing cue exposure therapy in cocaine-dependent people.
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DOI：
10.1101/lm.1027208
发表时间：
2008-10
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Duvarci S;Nader K;LeDoux JE
通讯作者：
LeDoux JE
影响因子：
3.6
作者：
GRECKSCH, G;MATTHIES, H
通讯作者：
MATTHIES, H
DOI：
10.1111/j.1460-9568.2009.06888.x
发表时间：
2009-09
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Fuchs RA;Bell GH;Ramirez DR;Eaddy JL;Su ZI
通讯作者：
Su ZI
影响因子：
56.9
作者：
Frankland, PW;Bontempi, B;Silva, AJ
通讯作者：
Silva, AJ
影响因子：
5.3
作者：
Frey, S;Bergado-Rosado, J;Frey, JU
通讯作者：
Frey, JU