Leptin in teleost fishes: an argument for comparative study.

Leptin in teleost fishes: an argument for comparative study.
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DOI:
10.3389/fphys.2011.00026
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发表时间:
2011
影响因子:
4
通讯作者:
Londraville RL
Londraville RL
中科院分区:
医学2区
文献类型:
--
作者:
Copeland DL;Duff RJ;Liu Q;Prokop J;Londraville RL

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所有生物都面临着如何投资有限能源的权衡。什么时候最有利于生长和繁殖,有多少脂质应该储存起来,为资源有限的一段时间(如冬季)做准备,而不是用于生长或成熟?这些是一些高结果适应度的“决策”,代表了能量获取和分配之间的平衡。事实上,对于动物来说,为了在何时生长、进食或繁殖方面做出有利的决定,它们必须整合负责能量获取、储存和需求的系统之间的信号。我们认为瘦素信号可能是一个整合系统的候选者。对哺乳动物瘦素系统的了解已经取得了很大的进展,然而,我们对鱼类的了解一直受到克隆哺乳动物蛋白质的鱼类同源物的困难和(我们认为)比较方法利用不足的阻碍。
All organisms face tradeoffs with regard to how limited energy resources should be invested. When is it most favorable to grow, to reproduce, how much lipid should be allocated to storage in preparation for a period of limited resources (e.g., winter), instead of being used for growth or maturation? These are a few of the high consequence fitness “decisions” that represent the balance between energy acquisition and allocation. Indeed, for animals to make favorable decisions about when to grow, eat, or reproduce, they must integrate signals among the systems responsible for energy acquisition, storage, and demand. We make the argument that leptin signaling is a likely candidate for an integrating system. Great progress has been made understanding the leptin system in mammals, however our understanding in fishes has been hampered by difficulty in cloning fish orthologs of mammalian proteins and (we assert), underutilization of the comparative approach.
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