Speech disturbs face scanning in 6-month-old infants who develop autism spectrum disorder.
Speech disturbs face scanning in 6-month-old infants who develop autism spectrum disorder.
复制标题
DOI：
10.1016/j.biopsych.2013.07.009
复制
发表时间：
2014-02-01
影响因子：
10.6
通讯作者：
Chawarska, Katarzyna
中科院分区：
文献类型：
--
作者：
Shic, Frederick;Macari, Suzanne;Chawarska, Katarzyna
从出生开始，婴儿就表现出对他人面孔、目光和声音的偏好。在患有自闭症谱系障碍（ASDs）的个体中，这些偏见似乎受到了干扰。这些障碍的来源尚不清楚，但最近的研究表明，早在6个月大时，对社会目标的自发注意力部署可能是非典型的。这种非典型行为的性质及其产生的条件目前尚不清楚。我们使用眼动追踪技术来研究6个月大的婴儿（N=99）在观察(1)静止、(2)移动并表达积极情绪或(3)说话的面孔时，患ASD的高风险（HR； N=57）和低风险（LR； N=42）的注视模式。临床结果通过3岁时的综合评估确定。将后来诊断为ASD的婴儿的扫描模式与没有ASD结果的婴儿进行比较。后来发展为ASD的婴儿通常比其他婴儿花更少的时间看呈现的场景。当这些婴儿看脸时，只有当脸在说话时，他们对脸的内在特征的关注才比其他组少。我们的研究表明，后来被诊断为ASD的婴儿在调节对复杂社交场景的注意力方面存在困难。它还表明，当其他婴儿正在学习语言和学习社交世界时，言语的存在可能会独特地干扰后来发展为ASD的婴儿的注意力。
From birth, infants show a preference for the faces, gaze, and voices of others. In individuals with autism spectrum disorders (ASDs) these biases appear to be disturbed. The source of these disturbances is not well-understood, but recent efforts have shown that the spontaneous deployment of attention to social targets may be atypical as early as 6 months of age. The nature of this atypical behavior and the conditions under which it arises are currently unknown. We used eye-tracking to examine the gaze patterns of 6-month-old infants (N=99) at high risk (HR; N=57) and low risk (LR; N=42) for developing ASD as they viewed faces that were (1) still, (2) moving and expressing positive affect, or (3) speaking. Clinical outcomes were determined through a comprehensive assessment at the age of 3 years. The scanning patterns of infants later diagnosed with ASD were compared to infants without an ASD outcome. Infants who later developed ASD spent less time looking at the presented scenes in general than other infants. When these infants looked at faces, their looking towards the inner features of faces decreased compared to the other groups only when the presented face was speaking. Our study suggests that infants later diagnosed with ASD have difficulties regulating attention to complex social scenes. It also suggests that the presence of speech may uniquely disturb the attention of infants who later develop ASD at a critical developmental point when other infants are acquiring language and learning about their social world.
登录
查看更多内容
影响因子：
5.2
作者：
Barbaro, Josephine;Dissanayake, Cheryl
通讯作者：
Dissanayake, Cheryl
影响因子：
1.4
作者：
Boyd, Brian A.;Odom, Samuel L.;Sam, Ann M.
通讯作者：
Sam, Ann M.
DOI：
10.1111/j.1469-7610.2009.02101.x
发表时间：
2009-10-01
影响因子：
7.6
作者：
Chawarska, Katarzyna;Klin, Ami;Volkmar, Fred
通讯作者：
Volkmar, Fred
DOI：
10.1016/j.cub.2011.12.056
发表时间：
2012-02-21
期刊：
Current biology : CB
影响因子：
--
作者：
Elsabbagh M;Mercure E;Hudry K;Chandler S;Pasco G;Charman T;Pickles A;Baron-Cohen S;Bolton P;Johnson MH;BASIS Team
通讯作者：
BASIS Team
DOI：
10.1176/appi.ajp.2012.12091150
发表时间：
2013-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Elison JT;Paterson SJ;Wolff JJ;Reznick JS;Sasson NJ;Gu H;Botteron KN;Dager SR;Estes AM;Evans AC;Gerig G;Hazlett HC;Schultz RT;Styner M;Zwaigenbaum L;Piven J;IBIS Network
通讯作者：
IBIS Network