Correlation study between molecular structure of sesquiterpene lactones and the selective adsorption performance of molecularly imprinted polymers.
Correlation study between molecular structure of sesquiterpene lactones and the selective adsorption performance of molecularly imprinted polymers.
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倍半萜内酯分子结构与分子印迹聚合物选择性吸附性能的相关性研究
DOI：
10.1016/j.chroma.2014.05.043
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发表时间：
2014-08
影响因子：
4.1
通讯作者：
Pengfei Tu
中科院分区：
文献类型：
--
作者：
Xingxia Ma;Xudong Zhou;Mingbo Zhao;Pengfei Tu
我们初步报道了模板分子和靶组分的结构与分子印迹聚合物（MIPs）对倍半萜内酯的选择性吸附性能有关。模板分子涉及三种具有不同环系的倍半萜内酯：5-mem内酯环白术内酯III、7-mem内酯环脱氢木香内酯和10-mem内酯环木香内酯内酯，其构象通过变温1h NMR谱进行了验证。采用沉淀聚合法制备了互易型MIPs，并将其作为固相萃取柱的选择性吸附剂。利用这些柱进一步富集倍半萜内酯成分和参比成分的混合吸附溶液。最后以中草药木香提取物为实验对象，验证了该方法的有效性。我们的研究结果表明，分子的空间构象稳定性与其相应的MIPs的选择性吸附有关。我们进一步观察到，当靶分子的构象与模板分子的构象一致时，吸附量最大。加入更多亲水基团与较弱的MIPs吸附有关。我们的研究结果提供了重要的信息，有助于指导选择合适的模板分子来合成具有特异性吸附的MIPs。
We preliminarily report that the structure of template molecules and target components correlates with the selective adsorption performance of molecularly imprinted polymer (MIPs) in sesquiterpene lactones. Template molecules involved three categories of sesquiterpene lactones with distinct ring systems: 5-mem lactone ring atractylenolide III, 7-mem lactone ring dehydrocostus lactone, and 10-mem lactone ring costunolide lactone, of which the conformations were verified by variable-temperature1H NMR spectroscopy. Reciprocal MIPs were prepared by precipitation polymerization and employed as selective sorbents in the columns of solid phase extraction (SPE). These columns were further used for enriching the mixed adsorption solution of sesquiterpene lactone ingredients and reference components. Finally, the extract ofRadix Aucklandiae, a Chinese medicine herb, was used to verify the efficiency of this method. Our results demonstrate that the steric conformational stability of molecules is associated with the selective adsorption of their corresponding MIPs. We have further observed that the maximum adsorption capacity occurs when the target molecule conformation is consistent with that of the template molecule. The addition of more hydrophilic groups correlates with weaker adsorption of MIPs. Our findings provide important information to help guide the selection of appropriate template molecules for synthesis of MIPs with specific adsorption.
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影响因子：
6.1
作者：
Xing Chen;Zhaohui Zhang;Xiao Yang;Jiaxing Li;Yunan Liu;Hongjun Chen;Wei Rao;S. Yao
通讯作者：
Xing Chen;Zhaohui Zhang;Xiao Yang;Jiaxing Li;Yunan Liu;Hongjun Chen;Wei Rao;S. Yao
影响因子：
12.6
作者：
Wei Zhang;Xiwen He;Yang Chen;Wen-You Li;Yukui Zhang
通讯作者：
Wei Zhang;Xiwen He;Yang Chen;Wen-You Li;Yukui Zhang
分子印迹层包覆单分散球形二氧化硅微粒亲和富集葛根异黄酮苷
影响因子：
4.2
作者：
Luo, Jing;Zhang, Liying;Zhang, Zhongping
通讯作者：
Zhang, Zhongping
影响因子：
3.1
作者：
X. Yin;Yong-ming Luo;Jian-jiang Fu;You-quan Zhong;Qing-shan Liu
通讯作者：
X. Yin;Yong-ming Luo;Jian-jiang Fu;You-quan Zhong;Qing-shan Liu
影响因子：
6.1
作者：
Matsuda, H;Kagerura, T;Yoshikawa, M
通讯作者：
Yoshikawa, M