Amygdala-medial prefrontal cortex connectivity relates to stress and mental health in early childhood.
Amygdala-medial prefrontal cortex connectivity relates to stress and mental health in early childhood.
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DOI：
10.1093/scan/nsy017
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发表时间：
2018-04-01
影响因子：
4.2
通讯作者：
Mackey AP
中科院分区：
文献类型：
--
作者：
Park AT;Leonard JA;Saxler PK;Cyr AB;Gabrieli JDE;Mackey AP
早期生活压力与杏仁核和内侧前额叶皮层（mPFC）之间的功能连接中断有关，但目前尚不清楚杏仁核-mPFC连接中与压力相关的差异在发育早期出现了多少。在对79名4 ~ 7岁儿童的静息态功能连接（rs-FC）分析中，我们发现更多的不良经历与杏仁核-mPFC rs-FC较弱之间存在显著相关性。我们还发现，较弱的杏仁核mPFC rs-FC与较高水平的攻击性行为和注意力问题。这些发现表明，压力对情绪回路的影响在幼儿期就可以检测到，这种影响与心理健康问题有关。该回路的连通性可能有助于作为精神健康风险的标志，并用于跟踪早期干预的有效性。
Early life stress has been associated with disrupted functional connectivity between the amygdala and medial prefrontal cortex (mPFC), but it is unknown how early in development stress-related differences in amygdala–mPFC connectivity emerge. In a resting-state functional connectivity (rs-FC) analysis with 79 four- to seven-year-old children, we found a significant correlation between more adverse experiences and weaker amygdala–mPFC rs-FC. We also found that weaker amygdala–mPFC rs-FC was associated with higher levels of aggressive behavior and attention problems. These findings suggest that the impact of stress on emotional circuitry is detectable in early childhood and that this impact is associated with mental health difficulties. Connectivity in this circuit may be useful as a marker for mental health risk and for tracking the efficacy of early interventions.
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影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
3.2
作者：
Chai XJ;Ofen N;Gabrieli JD;Whitfield-Gabrieli S
通讯作者：
Whitfield-Gabrieli S
DOI：
10.1007/s10935-016-0452-5
发表时间：
2016-12
期刊：
The journal of primary prevention
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.1307893110
发表时间：
2013-09-24
影响因子：
11.1
作者：
Gee, Dylan G.;Gabard-Durnam, Laurel J.;Tottenham, Nim
通讯作者：
Tottenham, Nim
DOI：
10.1097/dbp.0b013e3182475267
发表时间：
2012-04
期刊：
Journal of developmental and behavioral pediatrics : JDBP
影响因子：
--
作者：
Biederman J;Petty CR;Day H;Goldin RL;Spencer T;Faraone SV;Surman CB;Wozniak J
通讯作者：
Wozniak J