Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making.
Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making.
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DOI：
10.1038/s41593-022-01245-9
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发表时间：
2023-03
影响因子：
25
通讯作者：
Churchland, Anne K. K.
中科院分区：
文献类型：
--
作者：
Musall, Simon;Sun, Xiaonan R. R.;Mohan, Hemanth;An, Xu;Gluf, Steven;Li, Shu-Jing;Drewes, Rhonda;Cravo, Emma;Lenzi, Irene;Yin, Chaoqun;Kampa, Bjoern M.;Churchland, Anne K. K.
要了解皮层回路如何产生复杂的行为，需要研究组成它们的细胞类型。在皮层区域内已经观察到不同锥体神经元（PyN）类型的功能差异，但不知道这些局部差异是否延伸到整个皮层，也不知道当考虑更大规模的动力学时是否会出现额外的差异。我们使用遗传和逆行标记来靶向锥体束、端脑内和皮质纹状体投射神经元，并测量它们在整个皮质范围内的活动。每种PyN类型都驱动着独特的神经动力学，无论是在局部还是在皮层范围内。听觉决策任务中的皮层活动和光遗传失活揭示了不同的功能作用。顶叶皮层中的所有PyNs都是在感知听觉刺激的过程中被招募的，但令人惊讶的是，锥体束神经元的因果作用最大。在额叶皮层，所有的PyNs需要准确的选择，但表现出不同的选择调谐。我们的研究结果表明，丰富的，特定类型的细胞皮质动力学形状的知觉决定。由发育谱系定义的不同皮质锥体神经元类型对行为决策做出独特的贡献。我们强调不同的皮质和皮质下区域之间的相互作用的重要性，成功的决策结果。
Understanding how cortical circuits generate complex behavior requires investigating the cell types that comprise them. Functional differences across pyramidal neuron (PyN) types have been observed within cortical areas, but it is not known whether these local differences extend throughout the cortex, nor whether additional differences emerge when larger-scale dynamics are considered. We used genetic and retrograde labeling to target pyramidal tract, intratelencephalic and corticostriatal projection neurons and measured their cortex-wide activity. Each PyN type drove unique neural dynamics, both at the local and cortex-wide scales. Cortical activity and optogenetic inactivation during an auditory decision task revealed distinct functional roles. All PyNs in parietal cortex were recruited during perception of the auditory stimulus, but, surprisingly, pyramidal tract neurons had the largest causal role. In frontal cortex, all PyNs were required for accurate choices but showed distinct choice tuning. Our results reveal that rich, cell-type-specific cortical dynamics shape perceptual decisions. Distinct cortical pyramidal neuron types, defined by developmental lineage, make unique contributions to behavioral decisions. We highlight the importance of interactions among diverse cortical and subcortical areas for successful decision outcomes.
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