Rapid development of motion-streak coding in the mouse visual cortex.
Rapid development of motion-streak coding in the mouse visual cortex.
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DOI：
10.1016/j.isci.2022.105778
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发表时间：
2023-01-20
期刊：
影响因子：
5.8
通讯作者：
Cang, Jianhua
中科院分区：
文献类型：
--
作者：
Tohmi, Manavu;Cang, Jianhua
尽管它的重要性，更高的视觉区域（HVA）在细胞分辨率的发展仍然在很大程度上未知。在这里，我们进行了双光子钙成像小鼠HVAs lateromedial（LM）和前外侧（AL）和V1观察视觉反应特性的发育变化。HVA神经元在睁眼时表现出与V1神经元相似的定向和方向选择性，在接下来的几周内变得更加尖锐。在所有发育阶段的所有区域的神经元倾向于选择性地响应点移动沿着轴垂直于他们的首选方向在缓慢的速度，这表明一定程度的传统运动编码已经在眼睛睁开。相比之下，在高速度下，许多神经元对沿着平行于首选方向的轴移动的点做出反应，但在眼睛睁开后很少，这表明在早期阶段缺乏运动条纹编码。总之，我们的研究结果揭示了HVAs视觉特性的发展。本文观察了小鼠HVA视觉反应特性的发育变化，HVA细胞具有方向选择性，在睁眼后立即具有较低的OSI，HVA神经元的OSI在睁眼后一周内迅速增加。
Despite its importance, the development of higher visual areas (HVAs) at the cellular resolution remains largely unknown. Here, we conducted 2-photon calcium imaging of mouse HVAs lateromedial (LM) and anterolateral (AL) and V1 to observe developmental changes in visual response properties. HVA neurons showed selectivity for orientations and directions similar to V1 neurons at eye opening, which became sharper in the following weeks. Neurons in all areas over all developmental stages tended to respond selectively to dots moving along an axis perpendicular to their preferred orientation at slow speeds, suggesting a certain level of conventional motion coding already at eye opening. In contrast, at high speeds, many neurons responded to dots moving along the axis parallel to the preferred orientation in older animals but rarely after eye opening, indicating a lack of motion-streak coding in the earlier stage. Together, our results uncover the development of visual properties in HVAs. Developmental changes in visual response properties of mouse HVAs are observed HVA cells are orientation selective with lower OSI immediately after eye opening OSI of HVA neurons rapidly increases within one week after eye opening Motion-streak coding of visual cortical neurons develops rapidly after eye opening Biological sciences; Neuroscience; Developmental neuroscience; Sensory neuroscience.
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