Both infected and uninfected mosquitoes are attracted toward malaria infected birds.

Both infected and uninfected mosquitoes are attracted toward malaria infected birds.
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DOI:
10.1186/1475-2875-12-179
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发表时间:
2013-06-03
期刊:
影响因子:
3
通讯作者:
Gandon S
Gandon S
中科院分区:
医学3区
文献类型:
--
作者:
Cornet S;Nicot A;Rivero A;Gandon S

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蚊子的叮咬行为对疟疾寄生虫的传播至关重要。本研究的重点是喂养行为的尖音库蚊的感染状况,由禽疟疾寄生虫残留疟原虫(谱系SGS1)。未感染和子孢子感染的蚊子在未感染的鸟和经历慢性P.relictum感染的鸟之间进行选择。通过摄入血液的微卫星分型来评估蚊子的选择。慢性感染的鸟类对蚊子更有吸引力。这种选择不会因蚊子的感染状况而改变:感染和未感染的蚊子都有类似的宿主选择行为,更容易被感染的鸟类吸引。这些结果支持了一些但不是所有的预测,这些预测来自疟疾寄生虫可以操纵其蚊子媒介的行为以增强其传播的假设。驱动这种操作的可能机制,进化动力学导致修改蚊子的叮咬行为的疟原虫以及疟疾流行病学的影响进行了讨论。
The biting behaviour of mosquitoes is crucial for the transmission of malaria parasites. This study focuses on the feeding behaviour of Culex pipiens mosquitoes with regard to the infection status by the avian malaria parasite Plasmodium relictum (lineage SGS1). Uninfected and sporozoite-infected mosquitoes were provided with a choice between an uninfected bird and a bird undergoing a chronic P. relictum infection. Mosquito choice is assessed by microsatellite typing of the ingested blood. Chronically infected birds are more attractive to mosquitoes. This choice is not altered by the infection status of the mosquitoes: both infected and uninfected mosquitoes have similar host choice behaviours and are more attracted towards infected birds. These results support some, but not all predictions derived from the hypothesis that malaria parasites can manipulate the behaviour of their mosquito vectors to enhance their transmission. The possible mechanisms driving this manipulation, the evolutionary dynamics leading to the modification of the biting behaviour of mosquitoes by Plasmodium sp. as well as the implications for malaria epidemiology are discussed.
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