Lives and Costs Saved by Expanding and Expediting Coronavirus Disease 2019 Vaccination.
Lives and Costs Saved by Expanding and Expediting Coronavirus Disease 2019 Vaccination.
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DOI：
10.1093/infdis/jiab233
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发表时间：
2021-09-17
期刊：
影响因子：
--
通讯作者：
Lee BY
中科院分区：
文献类型：
--
作者：
Bartsch SM;Wedlock PT;O'Shea KJ;Cox SN;Strych U;Nuzzo JB;Ferguson MC;Bottazzi ME;Siegmund SS;Hotez PJ;Lee BY
随着2019冠状病毒病（COVID-19）疫苗的多种可用性，了解提高覆盖水平和加快疫苗接种的流行病学，临床和经济价值非常重要。我们开发了一个代表美国人口、COVID-19冠状病毒传播（2020年2月至2022年12月）和疫苗接种的计算模型（传播和年龄分层的临床和经济学结果模型），以确定增加覆盖率和加快实现覆盖的时间的影响。当在270天内实现给定的疫苗接种覆盖率（70%的疫苗效力）时，覆盖率每增加1%，平均可以避免876800例（217000 - 2398000）病例，这取决于已经接种疫苗的人数。例如，在40%到50%的覆盖率之间，每增加1%，就可以预防150万例病例、56240例住院和6660例死亡;获得77590个质量调整生命年;节省6.028亿美元的直接医疗费用和13亿美元的生产力损失。缩短到180天可以节省额外的580万例病例，215790例住院，26370例死亡，206520例死亡，35亿美元的直接医疗费用和43亿美元的生产力损失。我们的研究量化了减少疫苗犹豫和增加疫苗接种覆盖率的潜在价值，以及该价值如何随着实现覆盖率所需的时间而下降，强调需要尽快达到高覆盖率水平，特别是在秋季/冬季之前。我们的研究量化了减少疫苗犹豫，增加疫苗接种覆盖率的潜在价值，以及如何随着实现覆盖率所需的时间而减少，强调需要尽快达到高覆盖率水平，特别是在秋季/冬季之前。
With multiple coronavirus disease 2019 (COVID-19) vaccines available, understanding the epidemiologic, clinical, and economic value of increasing coverage levels and expediting vaccination is important. We developed a computational model (transmission and age-stratified clinical and economics outcome model) representing the United States population, COVID-19 coronavirus spread (February 2020–December 2022), and vaccination to determine the impact of increasing coverage and expediting time to achieve coverage. When achieving a given vaccination coverage in 270 days (70% vaccine efficacy), every 1% increase in coverage can avert an average of 876 800 (217 000–2 398 000) cases, varying with the number of people already vaccinated. For example, each 1% increase between 40% and 50% coverage can prevent 1.5 million cases, 56 240 hospitalizations, and 6660 deaths; gain 77 590 quality-adjusted life-years (QALYs); and save $602.8 million in direct medical costs and $1.3 billion in productivity losses. Expediting to 180 days could save an additional 5.8 million cases, 215 790 hospitalizations, 26 370 deaths, 206 520 QALYs, $3.5 billion in direct medical costs, and $4.3 billion in productivity losses. Our study quantifies the potential value of decreasing vaccine hesitancy and increasing vaccination coverage and how this value may decrease with the time it takes to achieve coverage, emphasizing the need to reach high coverage levels as soon as possible, especially before the fall/winter. Our study quantifies the potential value of decreasing vaccine hesitancy, increasing vaccination coverage, and how this may decrease with the time it takes to achieve coverage, emphasizing the need to reach high coverage levels as soon as possible, especially before fall/winter.
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影响因子：
5.5
作者：
Bartsch SM;O'Shea KJ;Wedlock PT;Strych U;Ferguson MC;Bottazzi ME;Randall SL;Siegmund SS;Cox SN;Hotez PJ;Lee BY
通讯作者：
Lee BY
DOI：
10.15585/mmwr.mm7010e3
发表时间：
2021-03-12
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Guy GP Jr;Lee FC;Sunshine G;McCord R;Howard-Williams M;Kompaniyets L;Dunphy C;Gakh M;Weber R;Sauber-Schatz E;Omura JD;Massetti GM;CDC COVID-19 Response Team, Mitigation Policy Analysis Unit;CDC Public Health Law Program
通讯作者：
CDC Public Health Law Program
影响因子：
64.8
作者：
Johnson, Neil F.;Velasquez, Nicolas;Lupu, Yonatan
通讯作者：
Lupu, Yonatan
影响因子：
5.5
作者：
Bartsch, Sarah M.;O'Shea, Kelly J.;Lee, Bruce Y.
通讯作者：
Lee, Bruce Y.
影响因子：
9.7
作者：
Bartsch, Sarah M.;Ferguson, Marie C.;Lee, Bruce Y.
通讯作者：
Lee, Bruce Y.