The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity.
The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity.
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DOI：
10.3389/fendo.2022.981487
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
骨质疏松症被定义为一种全身性骨骼疾病，其特征是骨量减少，微结构恶化，导致骨折风险增加。在绝经后女性和老年男性中，骨质疏松症的发病率都随着年龄的增长而增加。在骨质疏松症中观察到的其他影响骨脆性的重要因素中，也影响老年人口的还有肥胖和2型糖尿病(T2D)中观察到的代谢障碍。这些代谢并发症与骨骼内环境平衡受损和较高的骨折风险有关。骨髓脂肪组织(BMAT)的扩张以骨形成减少为代价，被认为是肥胖和T2D导致骨质疏松症和骨脆性的关键发病机制之一。我们的综述总结了衰老过程中骨髓脂肪(BMA)增加的机制，并重点介绍了肥胖与T2D、BMA与老年骨质疏松女性和男性骨脆性之间的临床前和临床研究。
Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis incidence increases with age in both post-menopausal women and aging men. Among other important contributing factors to bone fragility observed in osteoporosis, that also affect the elderly population, are metabolic disturbances observed in obesity and Type 2 Diabetes (T2D). These metabolic complications are associated with impaired bone homeostasis and a higher fracture risk. Expansion of the Bone Marrow Adipose Tissue (BMAT), at the expense of decreased bone formation, is thought to be one of the key pathogenic mechanisms underlying osteoporosis and bone fragility in obesity and T2D. Our review provides a summary of mechanisms behind increased Bone Marrow Adiposity (BMA) during aging and highlights the pre-clinical and clinical studies connecting obesity and T2D, to BMA and bone fragility in aging osteoporotic women and men.
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影响因子：
5.2
作者：
Aaron N;Costa S;Rosen CJ;Qiang L
通讯作者：
Qiang L
DOI：
10.1038/oby.2010.106
发表时间：
2011-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bredella MA;Torriani M;Ghomi RH;Thomas BJ;Brick DJ;Gerweck AV;Rosen CJ;Klibanski A;Miller KK
通讯作者：
Miller KK
DOI：
10.1016/j.ecl.2012.04.006
发表时间：
2012-09-01
影响因子：
4.5
作者：
Armas, Laura A. G.;Recker, Robert R.
通讯作者：
Recker, Robert R.
影响因子：
4.1
作者：
Ali, Dalia;Chen, Li;Alfayez, Musaad
通讯作者：
Alfayez, Musaad
骨质变化与衰老和疾病有关：评论。
影响因子：
5.2
作者：
Boskey AL;Imbert L
通讯作者：
Imbert L