Childhood adversity and inflammatory processes in youth: a prospective study.
Childhood adversity and inflammatory processes in youth: a prospective study.
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儿童逆境和青年炎症过程：一项前瞻性研究。
DOI：
10.1016/j.psyneuen.2012.05.013
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发表时间：
2013-02
影响因子：
3.7
通讯作者：
Koenen, Karestan C.
中科院分区：
文献类型：
--
作者：
Slopen, Natalie;Kubzansky, Laura D.;McLaughlin, Katie A.;Koenen, Karestan C.
关键词：
回顾性研究表明，童年的逆境与成年后的全身炎症有关。很少有前瞻性研究探讨童年逆境是否会在童年或青春期以可观察的方式影响炎症，以及这些影响是否会随着时间的推移而持续。使用雅芳父母和儿童纵向研究的纵向数据，我们研究了8岁之前7个时间点的急性不良事件与10岁和15岁时炎症之间的关联。10岁时的炎症标志物包括白细胞介素-6（IL-6; N = 4655）和C反应蛋白（CRP; N = 4647），15岁时再次测量CRP（N = 3286）。我们进一步评估了体重指数（BMI）、抑郁症或吸烟是否介导了不良事件和炎症之间的关联。儿童中期（发生在6至8岁之间）的不良事件，以及从出生到8岁的累积逆境，与10岁时IL-6和CRP水平较高相关。儿童早期（1.5岁）或儿童中期报告的不良事件，以及从出生到8岁的累积逆境预测15岁时CRP水平升高，这些相关性在10岁时校正CRP后持续存在。其中一些，但不是全部，由BMI介导。这项研究记录了8岁之前暴露于不良事件与10岁和青春期中期炎症升高相关。这些发现为早期经历可能塑造长期健康的生物学机制提供了前瞻性证据。未来的研究与炎症的早期评估是必要的，以阐明潜在的敏感期和机制，儿童逆境，后来的疾病脆弱性。
Retrospective studies show that childhood adversity is associated with systemic inflammation in adulthood. Few prospective studies have examined whether childhood adversity influences inflammation in an observable manner during childhood or adolescence and if these effects are sustained over time. Using longitudinal data from the Avon Longitudinal Study of Parents and Children, we examined associations between acute adverse events at seven time points prior to age 8 and inflammation at ages 10 and 15. Inflammatory markers at age 10 included interleukin-6 (IL-6; N = 4655) and C-reactive protein (CRP; N = 4647), and CRP was measured again at age 15 (N = 3286). We further evaluated whether body mass index (BMI), depression, or cigarette smoking mediated associations between adverse events and inflammation. Adverse events in middle childhood (occurring between ages 6 to 8), as well as cumulative adversity from birth to 8 years, were associated with higher levels of IL-6 and CRP at age 10. Adverse events reported in early childhood (1.5 years) or middle childhood, and cumulative adversity from birth through 8 years predicted increased levels of CRP at age 15, and these associations persisted after adjustment for CRP at age 10. Some, but not all, of these associations were mediated by BMI. This study documents that exposure to adverse events prior to age 8 is associated with elevated inflammation at age 10 and in mid-adolescence. These findings provide prospective evidence for a biological mechanism by which early experiences may shape long-term health. Future studies with earlier assessments of inflammation are necessary in order to elucidate potential sensitive periods and mechanisms that link childhood adversity to later disease vulnerability.
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影响因子：
7.7
作者：
Gimeno, D.;Ferrie, J. E.;Kivimaki, M.
通讯作者：
Kivimaki, M.
影响因子：
7.6
作者：
Angold, A;Erkanli, A;Costello, EJ
通讯作者：
Costello, EJ
影响因子：
--
作者：
Danese, Andrea;Moffitt, Terrie E.;Harrington, HonaLee;Milne, Barry J.;Polanczyk, Guilherme;Pariante, Carmine M.;Poulton, Richie;Caspi, Avshalom
通讯作者：
Caspi, Avshalom
影响因子：
5.8
作者：
Golding, J
通讯作者：
Golding, J
DOI：
10.1016/j.pedn.2008.02.034
发表时间：
2009-10-01
期刊：
Journal of pediatric nursing
影响因子：
--
作者：
Dixon, Denise;Meng, Hongdao;Delamater, Alan
通讯作者：
Delamater, Alan