Effect of dietary omega-3 polyunsaturated Fatty acids on heart rate and heart rate variability in animals susceptible or resistant to ventricular fibrillation.
Effect of dietary omega-3 polyunsaturated Fatty acids on heart rate and heart rate variability in animals susceptible or resistant to ventricular fibrillation.
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DOI：
10.3389/fphys.2012.00071
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发表时间：
2012
影响因子：
4
通讯作者：
Billman GE
中科院分区：
文献类型：
--
作者：
Billman GE
据报道，ω-3多不饱和脂肪酸（n−3 PUFA）的摄入可降低心肌梗死后的心脏死亡率，并降低静息心率（HR）和增加HR变异性（HRV）。然而，尚未确定n-3 PUFAs是否对已知易患或抵抗心室颤动（VF）的个体的HR和HRV表现出相同的作用。因此，在心肌梗死愈合犬中，在n-3 PUFA治疗前和治疗后3个月，评价HR和HRV（高频和总R-R间期变异性），这些犬对次极量运动试验最后一分钟期间2分钟冠状动脉闭塞诱导的室性快速性心律失常易感（VF+，n = 31）或抵抗（VF-，n = 31）。在安慰剂（1 g/天，玉米油，VF+，n = 9; VF−，n = 8）或n−3 PUFA（二十二碳六烯酸+二十碳五烯酸乙酯，1-4 g/天，VF+，n = 22; VF−，n = 23）治疗3个月之前和之后，在静息时、亚极量运动期间以及对静息时急性心肌缺血的反应中评估HR和HRV。VF+和VF-犬的n-3 PUFA治疗引起红细胞膜、右心房和左心室n-3 PUFA水平的相似增加。n-3 PUFA治疗也引起两组基线HR的相似降低和基线HRV的增加，导致对运动或急性心肌缺血反应的平行变化（即，由生理挑战引起的这些变量的变化在n-3 PUFA治疗后没有改变）。这些数据表明，饮食n-3 PUFA降低HR和增加HRV的程度与已知易患或耐恶性快速性心律失常的动物相似。
The consumption of omega-3 polyunsaturated fatty acids (n−3 PUFAs) has been reported to reduce cardiac mortality following myocardial infarction as well as to decrease resting heart rate (HR) and increase HR variability (HRV). However, it has not been established whether n−3 PUFAs exhibit the same actions on HR and HRV in individuals known to be either susceptible or resistant to ventricular fibrillation (VF). Therefore, HR and HRV (high frequency and total R–R interval variability) were evaluated before and 3 months after n−3 PUFA treatment in dogs with healed myocardial infarction that were either susceptible (VF+, n = 31) or resistant (VF−, n = 31) to ventricular tachyarrhythmias induced by a 2-min coronary artery occlusion during the last minute of a submaximal exercise test. HR and HRV were evaluated at rest, during submaximal exercise and in response to acute myocardial ischemia at rest before and after either placebo (1 g/day, corn oil, VF+, n = 9; VF− n = 8) or n−3 PUFA (docosahexaenoic acid + eicosapentaenoic acid ethyl esters, 1–4 g/day, VF+, n = 22; VF−, n = 23) treatment for 3 months. The n−3 PUFA treatment elicited similar increases in red blood cell membrane, right atrial, and left ventricular n−3 PUFA levels in both the VF+ and VF− dogs. The n−3 PUFA treatment also provoked similar reductions in baseline HR and increases in baseline HRV in both groups that resulted in parallel shifts in the response to either exercise or acute myocardial ischemia (that is, the change in these variables induced by physiological challenges was not altered after n−3 PUFA treatment). These data demonstrate that dietary n−3 PUFA decreased HR and increased HRV to a similar extent in animals known to be prone to or resistant to malignant cardiac tachyarrhythmias.
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影响因子：
158.5
作者：
Albert, CM;Campos, H;Ma, J
通讯作者：
Ma, J
影响因子：
4
作者：
Billman GE
通讯作者：
Billman GE
DOI：
10.1161/circep.111.966739
发表时间：
2012-06-01
期刊：
Circulation. Arrhythmia and electrophysiology
影响因子：
--
作者：
Billman GE;Carnes CA;Adamson PB;Vanoli E;Schwartz PJ
通讯作者：
Schwartz PJ
影响因子：
--
作者：
COLLINS, MN;BILLMAN, GE
通讯作者：
BILLMAN, GE
DOI：
10.1152/ajpheart.01065.2009
发表时间：
2010-04-01
影响因子：
4.8
作者：
Billman, George E.;Nishijima, Yoshinori;Janssen, Paul M. L.
通讯作者：
Janssen, Paul M. L.