Farming lifestyle and human milk: Modulation of the infant microbiome and protection against allergy.
Farming lifestyle and human milk: Modulation of the infant microbiome and protection against allergy.
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DOI：
10.1111/apa.16147
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Järvinen KM
中科院分区：
文献类型：
--
作者：
Jackson CM;Mahmood MM;Järvinen KM
食物过敏、特应性湿疹、过敏性鼻炎和哮喘等多种过敏症状的患病率有所增加。对于为什么会发生这种情况，人们提出了几种解释，但主要因素之一可能是过敏流行地区随着时间的推移，微生物暴露逐渐减少。这种暴露发生在实行传统农业生活方式并受到保护以免受过敏的个体中。在这些农业社区更常见的婴儿食用母乳可能提供对抗过敏的另一种选择，因为众所周知，母乳有益于婴儿健康。在这篇综述中，我们介绍了母乳及其在塑造肠道微生物群中的作用，促进双歧杆菌等有益细菌的生长，以及农业生活方式、母乳和双歧杆菌对婴儿免疫力发展的下游影响。
There has been an increased prevalence of several allergic manifestations such as food allergy, atopic eczema, allergic rhinitis, and asthma. Several explanations have been proposed why this has occurred, but one of the main contributing factors may be the gradual loss of microbial exposures over time in regions where allergy is prevalent. Such exposures occur in individuals who practice a traditional farming lifestyle and are protected against allergy. Infant consumption of human milk, more commonly practiced in these farming communities may provide an alternative in combatting allergy, as it known to be beneficial to infant health. In this review we cover human milk and its role in shaping the gut microbiome promoting the growth of beneficial bacteria like Bifidobacterium, as well as the downstream impact of the farming lifestyle, human milk and Bifidobacterium has on developing infant immunity.
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