Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety Disorder.
Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety Disorder.
复制标题
患有重度抑郁症或社交焦虑症的非合并症初治患者的灰质异常
DOI：
10.1016/j.ebiom.2017.06.013
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发表时间：
2017-07
期刊：
影响因子：
11.1
通讯作者：
Lui S
中科院分区：
文献类型：
--
作者：
Zhao Y;Chen L;Zhang W;Xiao Y;Shah C;Zhu H;Yuan M;Sun H;Yue Q;Jia Z;Zhang W;Kuang W;Gong Q;Lui S
重度抑郁症（MDD）和社交焦虑症（SAD）之间的临床症状重叠表明这两种疾病表现出相似的大脑机制。然而，很少有研究直接比较这两种疾病的大脑结构。本研究的目的是评估非共病药物初治MDD患者和SAD患者之间的灰质体积（GMV）和皮质厚度变化。高分辨率T1加权图像采集自37名非共病MDD患者，24名非共病SAD患者和41名健康对照（HC）。对GMV进行基于体素的形态测定分析（用p < 0.001的错误发现率校正）和对皮质厚度进行基于顶点的分析（用p < 0.001的聚类概率校正），并通过ANOVA和事后检验比较组间差异。相对于HC，MDD患者和SAD患者均显示以下结果：双侧眶额皮质（OFC）、壳核和丘脑的GMV减少;双侧内侧前额叶皮质、后背外侧前额叶皮质、岛叶皮质、左颞极和右上级顶叶皮质增厚;左侧眶额皮质和双侧吻侧中额叶皮质变薄。此外，MDD患者的左侧梭状回和右侧枕叶外侧皮质厚度更大，双侧舌侧和左侧楔叶厚度更薄。SAD患者的右中央前皮质厚度明显变薄。我们的研究结果表明，MDD和SAD共享共同的模式，在眶额-纹状体-丘脑回路，显著性网络和背侧注意网络的灰质异常。两个患者组中这些一致的结构差异可能导致在MDD患者和SAD患者中观察到的广泛的情绪、认知和行为障碍。此外，我们还发现MDD患者的视觉加工区和SAD患者的中央前皮层的异常特异性受累。这些发现提供了新的证据，共同的和特定的神经病理机制，基础MDD和SAD。MDD和SAD在眶额-纹状体-丘脑回路、显著性和背侧注意网络中有共同的灰质异常。MDD患者表现出视觉处理区域的障碍特异性参与。SAD患者表现出中央前皮质的异常特异性受累。重度抑郁症（MDD）和社交焦虑症（SAD）之间的临床症状重叠表明这两种疾病的大脑机制相似。然而，很少有研究直接比较这两种疾病的大脑结构。本研究的目的是评估非共病药物初治MDD患者和SAD患者之间的灰质体积和皮质厚度变化。我们发现MDD和SAD在眶额-纹状体-丘脑回路、显著性网络和背侧注意网络中有共同的灰质异常模式。MDD患者表现出视觉处理区域的障碍特异性参与。SAD患者表现出中央前皮质的异常特异性受累。
An overlap of clinical symptoms between major depressive disorder (MDD) and social anxiety disorder (SAD) suggests that the two disorders exhibit similar brain mechanisms. However, few studies have directly compared the brain structures of the two disorders. The aim of this study was to assess the gray matter volume (GMV) and cortical thickness alterations between non-comorbid medication-naive MDD patients and SAD patients. High-resolution T1-weighted images were acquired from 37 non-comorbid MDD patients, 24 non-comorbid SAD patients and 41 healthy controls (HCs). Voxel-based morphometry analysis of the GMV (corrected with a false discovery rate of p < 0.001) and vertex-based analysis of cortical thickness (corrected with a clusterwise probability of p < 0.001) were performed, and group differences were compared by ANOVA followed by post hoc tests. Relative to the HCs, both the MDD patients and SAD patients showed the following results: GMV reductions in the bilateral orbital frontal cortex (OFC), putamen, and thalamus; cortical thickening in the bilateral medial prefrontal cortex, posterior dorsolateral prefrontal cortex, insular cortex, left temporal pole, and right superior parietal cortex; and cortical thinning in the left lateral OFC and bilateral rostral middle frontal cortex. In addition, MDD patients specifically showed a greater thickness in the left fusiform gyrus and right lateral occipital cortex and a thinner thickness in the bilateral lingual and left cuneus. SAD patients specifically showed a thinner cortical thickness in the right precentral cortex. Our results indicate that MDD and SAD share common patterns of gray matter abnormalities in the orbitofrontal-striatal-thalamic circuit, salience network and dorsal attention network. These consistent structural differences in the two patient groups may contribute to the broad spectrum of emotional, cognitive and behavioral disturbances observed in MDD patients and SAD patients. In addition, we found disorder-specific involvement of the visual processing regions in MDD and the precentral cortex in SAD. These findings provide new evidence regarding the shared and specific neuropathological mechanisms that underlie MDD and SAD. MDD and SAD share common gray matter abnormalities in the orbitofrontal-striatal-thalamic circuit, salience and dorsal attention network. MDD patients show disorder-specific involvement of the visual processing regions. SAD patients show disorder-specific involvement of the precentral cortex. An overlap of clinical symptoms between major depressive disorder (MDD) and social anxiety disorder (SAD) suggests similar brain mechanisms for the two disorders. However, few studies have directly compared the brain structures of the two disorders. The aim of this study was to assess gray matter volume and cortical thickness alterations between non-comorbid medication-naive MDD patients and SAD patients. We found that MDD and SAD shared a common pattern of gray matter abnormalities in the orbitofrontal-striatal-thalamic circuit, salience network and dorsal attention network. MDD patients showed disorder-specific involvement of the visual processing regions. SAD patients showed disorder-specific involvement of the precentral cortex.
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影响因子：
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作者：
Beesdo, Katja;Bittner, Antje;Wittchen, Hans-Ulrich
通讯作者：
Wittchen, Hans-Ulrich
DOI：
10.1016/j.pnpbp.2011.09.014
发表时间：
2012-01-10
影响因子：
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