Is low iron status a risk factor for neural tube defects?
Is low iron status a risk factor for neural tube defects?
复制标题
DOI：
10.1002/bdra.23223
复制
发表时间：
2014-02
影响因子：
--
通讯作者：
Mills, James L.
中科院分区：
文献类型：
--
作者：
Molloy, Anne M.;Einri, Caitriona Nic;Jain, Divyanshu;Laird, Eamon;Fan, Ruzong;Wang, Yifan;Scott, John M.;Shane, Barry;Brody, Lawrence C.;Kirke, Peadar N.;Mills, James L.
叶酸补充剂可以防止神经管缺陷（NTD）。低叶酸和低维生素B12的状态可能是孕妇患NTD的危险因素。然而，并不是所有的NTD都可以通过足够的叶酸/ B12状态来预防，可能还涉及其他潜在的可改变因素。叶酸和维生素B12的状态与铁代谢有重要联系。动物研究支持缺铁状态和NTD之间的关联，但人类数据很少。我们在一项以妊娠人群为基础的队列研究中对低铁状态的相关性进行了巢式NTD病例对照研究。在1986年至1990年期间招募了孕妇，当时怀孕早期补充维生素或铁很少。在平均妊娠14周时采集血液样本，用于测量64名NTD影响妊娠的妇女和207名未受影响妊娠的妇女的铁蛋白和血红蛋白。在NTD受累和未受累妊娠之间未观察到母体铁蛋白或血红蛋白浓度的显著差异（病例中位铁蛋白为16.8μg/L，血红蛋白为12.4g/dL，对照组为15.4μg/L和12.3g/dL）。如前所述，病例中红细胞叶酸和维生素B12浓度显著降低。此外，铁状态与NTD病变类型（无脑畸形或脊柱裂）无显著相关性。我们得出结论，妊娠早期母亲铁状态低不是NTD的独立危险因素。在叶酸中加入铁元素用于围产期使用可能会改善铁的状况，但不太可能预防NTD。
Folic acid supplements can protect against neural tube defects (NTDs). Low folate and low vitamin B12 status may be maternal risk factors for having an NTD affected pregnancy. However, not all NTDs are preventable by having an adequate folate/ B12 status and other potentially modifiable factors may be involved. Folate and vitamin B12 status have important links to iron metabolism. Animal studies support an association between poor iron status and NTDs but human data are scarce. We examined the relevance of low iron status in a nested NTD case-control study of women within a pregnant population-based cohort. Pregnant women were recruited between 1986 and 1990, when vitamin or iron supplementation in early pregnancy was rare. Blood samples, taken at an average of 14 weeks gestation, were used to measure ferritin and hemoglobin in 64 women during an NTD affected pregnancy and 207 women with unaffected pregnancies. No significant differences in maternal ferritin or hemoglobin concentrations were observed between NTD affected and non-affected pregnancies (case median ferritin 16.8μg/L and hemoglobin 12.4g/dL versus 15.4μg/L and 12.3g/dL in controls). As reported previously, red cell folate and vitamin B12 concentrations were significantly lower in cases. Furthermore, there was no significant association of iron status with type of NTD lesion (anencephaly or spina bifida) We conclude that low maternal iron status during early pregnancy is not an independent risk factor for NTDs. Adding iron to folic acid for periconceptional use may improve iron status but is not likely to prevent NTDs.
登录
查看更多内容
影响因子：
29
作者：
Donovan, A;Lima, CA;Andrews, NC
通讯作者：
Andrews, NC
影响因子：
2.3
作者：
Felkner, MM;Suarez, L;Hendricks, K
通讯作者：
Hendricks, K
DOI：
10.1002/bdra.20675
发表时间：
2010-08
影响因子：
--
作者：
Carmichael, Suzan L.;Yang, Wei;Shaw, Gary M.
通讯作者：
Shaw, Gary M.
影响因子：
3.9
作者：
Cengiz, B;Söylemez, F;Çavdar, AO
通讯作者：
Çavdar, AO
影响因子：
4.2
作者：
Iannotti, LL;O'Brien, KO;Witter, FR
通讯作者：
Witter, FR