The posteromedial region of the default mode network shows attenuated task-induced deactivation in psychopathic prisoners.
The posteromedial region of the default mode network shows attenuated task-induced deactivation in psychopathic prisoners.
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DOI：
10.1037/neu0000118
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发表时间：
2015-05
期刊：
影响因子：
2.4
通讯作者：
Miller, Michael B.
中科院分区：
文献类型：
--
作者：
Freeman, Scott M.;Clewett, David V.;Bennett, Craig M.;Kiehl, Kent A.;Gazzaniga, Michael S.;Miller, Michael B.
精神病是一种人格障碍，症状包括缺乏同情心或悔恨，反社会行为和过度自我关注。以前的神经影像学研究已经将精神病与默认模式网络（DMN）功能障碍联系起来，DMN是一种大脑网络，在外部关注的任务中失活，在自我参照处理过程中更活跃。具体来说，DMN被发现在有精神病倾向的个体中，在外部关注的任务中保持相对活跃，这表明未能正确地去激活。然而，任务诱发的DMN功能障碍的确切程度和性质知之甚少，包括（a）犯罪精神病患者中特定DMN亚区受影响的程度，以及（B）这些亚区的活动如何与精神病患者的情感/人际和反社会/生活方式特征相关。精神病和22个低精神病囚犯确定组水平的DMN被分成6个子区域，和组的差异，任务引起的activitywere examined.ResultsIn一般情况下，DMN分区未能在基线以下的高精神病组失活。与低精神病组的一组比较本地化这种衰减的任务引起的失活后内侧皮质（MPC）区域的DMN。此外，多元回归分析显示，在MPC的活动与情感/人际特质的psychopaths.ConclusionThese研究结果表明，衰减失活的MPC亚区的DMN是内在的精神病，是一种模式，可能与情感的精神病特征，包括缺乏对他人的关注。（PsycInfo数据库记录（c）2022阿帕，保留所有权利）
ObjectivePsychopathy is a personality disorder with symptoms that include lack of empathy or remorse, antisocial behavior, and excessive self-focus. Previous neuroimaging studies have linked psychopathy to dysfunction in the default mode network (DMN), a brain network that deactivates during externally focused tasks and is more engaged during self-referential processing. Specifically, the DMN has been found to remain relatively active in individuals with psychopathic tendencies during externally focused tasks, suggesting a failure to properly deactivate. However, the exact extent and nature of task-induced DMN dysfunction is poorly understood, including (a) the degree to which specific DMN subregions are affected in criminal psychopaths, and (b) how activity in these subregions relates to affective/interpersonal and antisocial/lifestyle traits of psychopathy.MethodWe performed a group independent component analysis to assess DMN activation during a Go/NoGo task in a group of 22 high-psychopathy and 22 low-psychopathy prisoners. The identified group-level DMN was parcellated into 6 subregions, and group differences in task-induced activity were examined.ResultsIn general, DMN subregions failed to deactivate beneath baseline in the high-psychopathy group. A group comparison with the low-psychopathy group localized this attenuated task-induced deactivation to the posteromedial cortical (mPC) region of the DMN. Moreover, multiple regression analyses revealed that activity in the mPC was associated with affective/interpersonal traits of psychopathy.ConclusionThese findings suggest that attenuated deactivation of the mPC subregion of the DMN is intrinsic to psychopathy, and is a pattern that may be more associated with affective psychopathic traits, including lack of concern for others.(PsycInfo Database Record (c) 2022 APA, all rights reserved)
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.8
作者：
Juarez, Michelle;Kiehl, Kent A.;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.
影响因子：
4.2
作者：
Heatherton, Todd F.;Wyland, Carrie L.;Kelley, William M.
通讯作者：
Kelley, William M.
影响因子：
5.7
作者：
Fransson, Peter;Marrelec, Guillaume
通讯作者：
Marrelec, Guillaume
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.