Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother-infant pairs.
Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother-infant pairs.
复制标题
巴西母亲对的孕产妇困扰，DNA甲基化和胎儿编程。
DOI：
10.1002/dev.22352
复制
发表时间：
2023-01
影响因子：
2.2
通讯作者：
中科院分区：
文献类型：
--
作者：
母亲产前心理社会应激与婴儿下丘脑-垂体-肾上腺轴（HPAA）功能不良有关。虽然影响这一过程的生物学机制仍然未知，但DNA甲基化改变被认为是一种潜在的机制。我们调查了母亲产前心理困扰，婴儿唾液DNA甲基化和12个月时的应激生理之间的关联。通过对80名怀孕少女在怀孕早期和晚期的抑郁和焦虑来测量母亲的痛苦。在怀孕期间收集母体毛发皮质醇。从12个月大的婴儿中收集唾液样本，以量化三个压力相关基因（FKBP 5，NR 3C 1，OXTR）（n = 62）和昼夜皮质醇（n = 29）的DNA甲基化。多变量线性回归用于检验产前心理困扰与婴儿DNA甲基化和皮质醇之间的关系。妊娠晚期头发皮质醇浓度与FKBP 5的两个位点呈负相关（位点1：B = −22.33，p = 0.003;位点2：B = −15.60，p = 0.012）。妊娠晚期焦虑症状升高的母亲所生婴儿的OXTR 2 CpG 2甲基化水平较低（B =-2.17，p = 0.03），夜间唾液皮质醇水平较高（B = 0.41，p = 0.03）。此外，OXTR 2甲基化与夜间皮质醇呈负相关（B =-0.14，p值≤ .001）。据我们所知，我们的研究结果是第一个证据表明，催产素受体的甲基化可能有助于在婴儿期HPAA的调节。
Maternal prenatal psychosocial stress is associated with adverse hypothalamic–pituitary–adrenal axis (HPAA) function among infants. Although the biological mechanisms influencing this process remain unknown, altered DNA methylation is considered to be one potential mechanism. We investigated associations between maternal prenatal psychological distress, infant salivary DNA methylation, and stress physiology at 12 months. Mother’s distress was measured via depression and anxiety in early and late pregnancy in a cohort of 80 pregnant adolescents. Maternal hair cortisol was collected during pregnancy. Saliva samples were collected from infants at 12 months to quantify DNA methylation of three stress-related genes (FKBP5, NR3C1, OXTR) (n = 62) and diurnal cortisol (n = 29). Multivariable linear regression was used to test for associations between prenatal psychological distress, and infant DNA methylation and cortisol. Hair cortisol concentrations in late pregnancy were negatively associated with two sites of FKBP5 (site 1: B = −22.33, p = .003; site 2: B = −15.60, p = .012). Infants of mothers with elevated anxiety symptoms in late pregnancy had lower levels of OXTR2 CpG2 methylation (B = −2.17, p = .03) and higher evening salivary cortisol (B = 0.41, p = .03). Furthermore, OXTR2 methylation was inversely associated with evening cortisol (B = −0.14, p-value ≤ .001). Our results are, to our knowledge, the first evidence that the methylation of the oxytocin receptor may contribute to the regulation of HPAA during infancy.
登录
查看更多内容
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.5
作者：
Ferri, Cleusa P.;Mitsuhiro, Sandro S.;Barros, Marina C. M.;Chalem, Elisa;Guinsburg, Ruth;Patel, Vikram;Prince, Martin;Laranjeira, Ronaldo
通讯作者：
Laranjeira, Ronaldo
影响因子：
11
作者：
Cecil, C. A. M.;Lysenko, L. J.;Jaffee, S. R.;Pingault, J-B;Smith, R. G.;Relton, C. L.;Woodward, G.;McArdle, W.;Mill, J.;Barker, E. D.
通讯作者：
Barker, E. D.
影响因子：
3.7
作者：
Cardoso, Christopher;Kingdon, Danielle;Ellenbogen, Mark A.
通讯作者：
Ellenbogen, Mark A.
影响因子：
2.4
作者：
Conradt, Elisabeth;Ostlund, Brendan;Lester, Barry M.
通讯作者：
Lester, Barry M.