Fabrication and Functionalisation of Nanocarbon-Based Field-Effect Transistor Biosensors.

Fabrication and Functionalisation of Nanocarbon-Based Field-Effect Transistor Biosensors.
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DOI:
10.1002/cbic.202200282
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发表时间:
2022-12-05
期刊:
Chembiochem : a European journal of chemical biology
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其他
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基于纳米碳的场效应晶体管(NC-FET)生物传感器处于未来诊断技术的最前沿。通过将生物分子与导电碳基平台集成,高灵敏度实时多重传感成为可能。 NC-FET 凭借其占地面积小、便携性、易用性和无标记传感机制,成为快速扩展的现场护理测试、环境监测和生物传感领域的主要候选者。在这篇综述中,我们概述了 NC-FET 背后的基本操作机制、FET 器件的合成和制造以及生物传感应用功能化策略的发展。 下一代诊断:基于纳米碳的场效应晶体管 (NC-FET) 使用传入的目标分析物对电导产生门控效应。在这里,我们回顾了 NC-FET 背后的操作机制、带有受体生物分子的 NC-FET 的制造和功能化以及下游生物传感应用。
Nanocarbon‐based field‐effect transistor (NC‐FET) biosensors are at the forefront of future diagnostic technology. By integrating biological molecules with electrically conducting carbon‐based platforms, high sensitivity real‐time multiplexed sensing is possible. Combined with their small footprint, portability, ease of use, and label‐free sensing mechanisms, NC‐FETs are prime candidates for the rapidly expanding areas of point‐of‐care testing, environmental monitoring and biosensing as a whole. In this review we provide an overview of the basic operational mechanisms behind NC‐FETs, synthesis and fabrication of FET devices, and developments in functionalisation strategies for biosensing applications. Next‐generation diagnostics: Nanocarbon‐based field effect transistors (NC‐FETs) use incoming target analytes to impart a gating effect on conductance. Here, we review the operational mechanisms behind NC‐FETs, the fabrication and functionalisation of NC‐FETs with receptor biomolecules and downstream biosensing applications.
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