Polymicrobial Interactions of Oral Microbiota: a Historical Review and Current Perspective.

Polymicrobial Interactions of Oral Microbiota: a Historical Review and Current Perspective.
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口腔微生物群的多微生物相互作用:历史回顾与当前观点

DOI:
10.1128/mbio.00235-22
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发表时间:
2022-06-28
期刊:
影响因子:
6.4
通讯作者:
Lewin, Gina R.
Lewin, Gina R.
中科院分区:
生物学1区
文献类型:
--
作者:
Zhang, Mengshi;Whiteley, Marvin;Lewin, Gina R.

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口腔微生物群是非常多样化的,有超过700种微生物物种在个体中被鉴定出来,它们对我们的口腔健康和整体健康起着至关重要的作用。此外,由于口腔疾病,如龋齿(蛀牙)和牙周炎(牙龈疾病)是通过种间微生物相互作用介导的,这个社区作为一个重要的模型系统,研究复杂性和动态的多微生物相互作用。在这里,我们回顾了我们对口腔微生物组的理解的历史和最新进展,强调了口腔微生物组研究如何为我们对微生物群落的理解做出了重大贡献,对多种微生物疾病和微生物群落生态学具有广泛的影响。此外,我们探讨了与分析多微生物系统相关的创新和挑战,并提出了未来的研究方向。最后,我们提供了一个概念框架,系统地研究复杂社区内的微生物相互作用,而不仅限于口腔微生物群。
The oral microbiota is enormously diverse, with over 700 microbial species identified across individuals that play a vital role in the health of our mouth and our overall well-being. In addition, as oral diseases such as caries (cavities) and periodontitis (gum disease) are mediated through interspecies microbial interactions, this community serves as an important model system to study the complexity and dynamics of polymicrobial interactions. Here, we review historical and recent progress in our understanding of the oral microbiome, highlighting how oral microbiome research has significantly contributed to our understanding of microbial communities, with broad implications in polymicrobial diseases and across microbial community ecology. Further, we explore innovations and challenges associated with analyzing polymicrobial systems and suggest future directions of study. Finally, we provide a conceptual framework to systematically study microbial interactions within complex communities, not limited to the oral microbiota.
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