Parallel mechanisms encode direction in the retina.
Parallel mechanisms encode direction in the retina.
复制标题
DOI：
10.1016/j.neuron.2011.06.020
复制
发表时间：
2011-08-25
期刊：
影响因子：
16.2
通讯作者：
Awatramani GB
中科院分区：
文献类型：
--
作者：
Trenholm S;Johnson K;Li X;Smith RG;Awatramani GB
In the retina, presynaptic inhibitory mechanisms that shape directionally selective (DS) responses in output ganglion cells are well established. However, the nature of inhibition-independent forms of directional selectivity remains poorly defined. Here, we describe a genetically specified set of ON-OFF DS ganglion cells (DSGCs) that code anterior motion. This entire population of DSGCs exhibits asymmetric dendritic arborizations that orientate toward the preferred direction. We demonstrate that morphological asymmetries along with nonlinear dendritic conductances generate a centrifugal (soma-to-dendrite) preference that does not critically depend upon, but works in parallel with the GABAergic circuitry. We also show that in symmetrical DSGCs, such dendritic DS mechanisms are aligned with, or are in opposition to, the inhibitory DS circuitry in distinct dendritic subfields where they differentially interact to promote or weaken directional preferences. Thus, pre- and postsynaptic DS mechanisms interact uniquely in distinct ganglion cell populations, enabling efficient DS coding under diverse conditions.
登录
查看更多内容
影响因子：
64.8
作者：
Roska, B;Werblin, F
通讯作者：
Werblin, F
DOI：
10.1126/science.1189664
发表时间：
2010-09-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Branco T;Clark BA;Häusser M
通讯作者：
Häusser M
影响因子：
16.2
作者：
Lee, Seunghoon;Kim, Kyongmin;Zhou, Z. Jimmy
通讯作者：
Zhou, Z. Jimmy
影响因子：
64.8
作者：
Berry, MJ;Brivanlou, IH;Meister, M
通讯作者：
Meister, M
影响因子：
64.8
作者：
Euler, T;Detwiler, PB;Denk, W
通讯作者：
Denk, W