Nanostructured biomaterials for tissue engineered bone tissue reconstruction.
Nanostructured biomaterials for tissue engineered bone tissue reconstruction.
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DOI：
10.3390/ijms13010737
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发表时间：
2012
影响因子：
5.6
通讯作者：
Barbara Z
中科院分区：
文献类型：
--
作者：
Chiara G;Letizia F;Lorenzo F;Edoardo S;Diego S;Stefano S;Eriberto B;Barbara Z
骨组织工程策略正在成为骨组织重建中自体移植物和同种异体移植物的有吸引力的替代方案，特别是由于它们与纳米技术的结合。事实上，纳米结构生物材料模仿天然骨的细胞外基质（ECM），创造一个促进细胞粘附、增殖和分化的人工微环境。同时，从不同成体组织中轻松分离间充质干细胞（MSC）的可能性及其多谱系分化潜力使它们成为骨组织工程领域的有趣工具。本综述概述了最有前途的纳米结构生物材料，可单独使用或与间充质干细胞结合使用，这些材料在未来可用作骨替代品。最近的研究表明，由陶瓷/金属或陶瓷/聚合物制成的复合支架在骨传导性、成骨性和骨诱导性方面无疑比单一支架更有效。更好地了解间充质干细胞和纳米结构生物材料之间的相互作用必将有助于骨组织工程的进步。
Bone tissue engineering strategies are emerging as attractive alternatives to autografts and allografts in bone tissue reconstruction, in particular thanks to their association with nanotechnologies. Nanostructured biomaterials, indeed, mimic the extracellular matrix (ECM) of the natural bone, creating an artificial microenvironment that promotes cell adhesion, proliferation and differentiation. At the same time, the possibility to easily isolate mesenchymal stem cells (MSCs) from different adult tissues together with their multi-lineage differentiation potential makes them an interesting tool in the field of bone tissue engineering. This review gives an overview of the most promising nanostructured biomaterials, used alone or in combination with MSCs, which could in future be employed as bone substitutes. Recent works indicate that composite scaffolds made of ceramics/metals or ceramics/polymers are undoubtedly more effective than the single counterparts in terms of osteoconductivity, osteogenicity and osteoinductivity. A better understanding of the interactions between MSCs and nanostructured biomaterials will surely contribute to the progress of bone tissue engineering.
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作者：
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通讯作者：
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