EEG Correlates of Central Origin of Cancer-Related Fatigue.
EEG Correlates of Central Origin of Cancer-Related Fatigue.
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DOI：
10.1155/2020/8812984
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发表时间：
2020
影响因子：
3.1
通讯作者：
Yue GH
中科院分区：
文献类型：
--
作者：
Allexandre D;Seyidova-Khoshknabi D;Davis MP;Ranganathan VK;Siemionow V;Walsh D;Yue GH
癌症相关性疲劳(CRF)的神经生理学机制尚不清楚。在持续次最大收缩(SC)任务中对脑电进行了检查，以进一步了解我们先前的研究结果，即更大的中枢对CRF次最大收缩(SC)过程中早期疲劳的贡献。晚期癌症患者和匹配的健康对照组在接受神经肌肉测试和脑电记录的同时，进行肘屈肌SC，直到任务失败。分析左侧和右侧感觉运动皮质的脑电功率变化，并与简明疲劳量表(BFI)评分和诱发肌力(衡量中枢性疲劳的指标)进行关联。慢性肾功能衰竭患者SC期间脑电活动的变化与健康受试者不同，主要集中在对侧(疲劳肢体)的theta(4-8 Hz)和beta(12-30 Hz)频段，其变化与诱发的力有关。此外，SC期间伽玛频段(30-50 HZ)功率下降在CRF静息2 分钟后没有恢复到基线，这种影响与BFI评分相关。总之，患者在疲劳任务期间脑电活动的改变与SC期间的中枢疲劳或疲劳症状有关，这表明它在运动表现期间对CRF有潜在的贡献。这些信息应该指导制定和使用针对中枢神经系统的康复干预措施，以最大限度地促进功能恢复。
The neurophysiological mechanism of cancer-related fatigue (CRF) remains poorly understood. EEG was examined during a sustained submaximal contraction (SC) task to further understand our prior research findings of greater central contribution to early fatigue during SC in CRF. Advanced cancer patients and matched healthy controls performed an elbow flexor SC until task failure while undergoing neuromuscular testing and EEG recording. EEG power changes over left and right sensorimotor cortices were analyzed and correlated with brief fatigue inventory (BFI) score and evoked muscle force, a measure of central fatigue. Brain electrical activity changes during the SC differed in CRF from healthy subjects mainly in the theta (4-8 Hz) and beta (12-30 Hz) bands in the contralateral (to the fatigued limb) hemisphere; changes were correlated with the evoked force. Also, the gamma band (30-50 Hz) power decrease during the SC did not return to baseline after 2 min of rest in CRF, an effect correlated with BFI score. In conclusion, altered brain electrical activity during a fatigue task in patients is associated with central fatigue during SC or fatigue symptoms, suggesting its potential contribution to CRF during motor performance. This information should guide the development and use of rehabilitative interventions that target the central nervous system to maximize function recovery.
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影响因子：
3.8
作者：
Askren, Mary K.;Jung, Misook;Berman, Marc G.;Zhang, Min;Therrien, Barbara;Peltier, Scott;Ossher, Lynn;Hayes, Daniel F.;Reuter-Lorenz, Patricia A.;Cimprich, Bernadine
通讯作者：
Cimprich, Bernadine
影响因子：
4.2
作者：
Hampson, Johnson P.;Zick, Suzanna M.;Khabir, Tohfa;Wright, Benjamin D.;Harris, Richard E.
通讯作者：
Harris, Richard E.
影响因子：
4.7
作者：
Babiloni, Claudio;Del Percio, Claudio;Lupattelli, Tommaso
通讯作者：
Lupattelli, Tommaso
影响因子：
2
作者：
Ferrucci, Roberta;Vergari, Maurizio;Priori, Alberto
通讯作者：
Priori, Alberto
影响因子：
2.3
作者：
Flor-Henry, Pierre;Lind, John C.;Koles, Zoltan J.
通讯作者：
Koles, Zoltan J.