Sleep and circadian rhythms: pillars of health-a Keystone Symposia report.
Sleep and circadian rhythms: pillars of health-a Keystone Symposia report.
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DOI：
10.1111/nyas.14661
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发表时间：
2021-12
影响因子：
5.2
通讯作者：
St-Onge MP
中科院分区：
文献类型：
--
作者：
Cable J;Schernhammer E;Hanlon EC;Vetter C;Cedernaes J;Makarem N;Dashti HS;Shechter A;Depner C;Ingiosi A;Blume C;Tan X;Gottlieb E;Benedict C;Van Cauter E;St-Onge MP
人类昼夜节律系统由位于下丘脑视交叉上核的主时钟以及位于全身器官的外周分子钟组成。这些系统共同建立了与昼夜周期同步的正常睡眠-觉醒和饮食周期。一些生物和生理过程，如体温、血压、激素分泌、基因表达和免疫功能都有昼夜规律。现代生活的许多方面，如工作安排、旅行和社交活动，都可能导致睡眠-觉醒和饮食安排与生物钟不完全同步。在极端情况下，它会破坏和损害生理和心理参数，最终可能使人们患癌症、心血管疾病和代谢紊乱等慢性疾病的风险更高。了解调节睡眠的机制以及行为对睡眠和昼夜节律的影响可能最终导致对行为改变的见解，从而降低这些疾病的风险。2021年2月25日，睡眠、昼夜节律和时间生物学方面的专家在“睡眠与昼夜节律：健康的支柱”的基石研讨会上进行了虚拟会面，讨论了关于理解睡眠、昼夜节律、健康和疾病之间双向关系的最新研究。
The human circadian system consists of the master clock in the suprachiasmatic nuclei of the hypothalamus as well as peripheral molecular clocks located in organs throughout the body. Together, these systems establish normal sleep-wake and eating cycles synced to the day-night cycle. Several biologic and physiologic processes such as body temperature, blood pressure, hormone secretion, gene expression, and immune functions manifest diurnal patterns. Many facets of modern life, such as work schedules, travel, and social engagements, can lead to sleep-wake and eating schedules that are not completely in sync with the biological clock. In its extreme form, this can disrupt and impair physiological and psychological parameters that may ultimately put people at higher risk for chronic diseases like cancer, cardiovascular disease, and metabolic disorders. Understanding the mechanisms that regulate sleep and behavioral effects on sleep and circadian rhythms may ultimately lead to insights on behavioral changes that can lower the risk of these diseases. On February 25, 2021, experts in sleep, circadian rhythms, and chronobiology met virtually for the Keystone eSymposium “Sleep & Circadian Rhythms: Pillars of Health” to discuss the latest research on understanding the bi-directional relationships between sleep, circadian rhythms, and health and disease.
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影响因子：
3.5
作者：
Cogswell, D.;Bisesi, P.;Markwald, R. R.;Cruickshank-Quinn, C.;Quinn, K.;McHill, A.;Melanson, E. L.;Reisdorph, N.;Wright, K. P., Jr.;Depner, C. M.
通讯作者：
Depner, C. M.
影响因子：
11.1
作者：
Cermakova P;Eriksdotter M;Lund LH;Winblad B;Religa P;Religa D
通讯作者：
Religa D
影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
16.2
作者：
Cappuccio FP;D'Elia L;Strazzullo P;Miller MA
通讯作者：
Miller MA
影响因子：
9.9
作者：
Benedict, Christian;Blennow, Kaj;Cedernaes, Jonathan
通讯作者：
Cedernaes, Jonathan