Complex effects of temperature on mosquito immune function.
Complex effects of temperature on mosquito immune function.
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DOI：
10.1098/rspb.2012.0638
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发表时间：
2012-08-22
期刊：
影响因子：
--
通讯作者：
Thomas MB
中科院分区：
文献类型：
--
作者：
Murdock CC;Paaijmans KP;Bell AS;King JG;Hillyer JF;Read AF;Thomas MB
在过去的20年里，生态免疫学为环境因素如何塑造宿主免疫和宿主-寄生虫相互作用提供了很多见解。目前，这一思路在蚊虫免疫学研究中的应用还很有限。机制调查几乎总是在一组条件下进行，但媒介和寄生虫在一个可变的世界。我们强调环境温度如何塑造疟疾媒介斯氏按蚊的细胞和体液免疫反应（黑化，吞噬作用和免疫基因的转录）。一氧化氮合酶表达在30°C时达到峰值，天蚕素表达没有显示温度和体液黑化的主要影响，吞噬作用和防御素表达在18°C左右达到峰值。此外，免疫反应并不简单地与温度成比例，而是显示出温度、时间和免疫挑战性质之间的复杂相互作用。因此，在一组条件下观察到的免疫模式几乎不能为预测即使在略微不同的条件下的模式提供基础。这些定量和定性的影响，温度在很大程度上被忽视的载体生物学，但有显着的影响，从实验室到现场推断自然/转基因抗性机制和各种载体控制工具的效力。
Over the last 20 years, ecological immunology has provided much insight into how environmental factors shape host immunity and host–parasite interactions. Currently, the application of this thinking to the study of mosquito immunology has been limited. Mechanistic investigations are nearly always conducted under one set of conditions, yet vectors and parasites associate in a variable world. We highlight how environmental temperature shapes cellular and humoral immune responses (melanization, phagocytosis and transcription of immune genes) in the malaria vector, Anopheles stephensi. Nitric oxide synthase expression peaked at 30°C, cecropin expression showed no main effect of temperature and humoral melanization, and phagocytosis and defensin expression peaked around 18°C. Further, immune responses did not simply scale with temperature, but showed complex interactions between temperature, time and nature of immune challenge. Thus, immune patterns observed under one set of conditions provide little basis for predicting patterns under even marginally different conditions. These quantitative and qualitative effects of temperature have largely been overlooked in vector biology but have significant implications for extrapolating natural/transgenic resistance mechanisms from laboratory to field and for the efficacy of various vector control tools.
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影响因子：
2.9
作者：
Arrighi, Romanico B. G.;Debierre-Grockiege, Francoise;Faye, Ingrid
通讯作者：
Faye, Ingrid
DOI：
10.4269/ajtmh.1993.49.756
发表时间：
1993-12-01
影响因子：
3.3
作者：
FERDIG, MT;BEERNTSEN, BT;CHRISTENSEN, BM
通讯作者：
CHRISTENSEN, BM
影响因子：
2.9
作者：
HARDIE, LJ;FLETCHER, TC;SECOMBES, CJ
通讯作者：
SECOMBES, CJ
影响因子：
2.2
作者：
De Block, Marjan;Stoks, Robby
通讯作者：
Stoks, Robby
影响因子：
2.2
作者：
Adamo, SA
通讯作者：
Adamo, SA