Intra- and Inter-Scanner Reliability of Voxel-Wise Whole-Brain Analytic Metrics for Resting State fMRI.
Intra- and Inter-Scanner Reliability of Voxel-Wise Whole-Brain Analytic Metrics for Resting State fMRI.
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静息态 fMRI 体素全脑分析指标的扫描仪内和扫描仪间可靠性
DOI：
10.3389/fninf.2018.00054
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发表时间：
2018
影响因子：
3.5
通讯作者：
Zang YF
中科院分区：
文献类型：
--
作者：
Zhao N;Yuan LX;Jia XZ;Zhou XF;Deng XP;He HJ;Zhong J;Wang J;Zang YF
随着静息状态功能磁共振成像（RS-fMRI）的多中心研究越来越多地应用于神经精神病学研究，RS-fMRI的扫描仪内和扫描仪间可靠性变得越来越重要。低频波动幅度（ALFF）、区域均匀性（ReHo）和度中心性（DC）是RS-fMRI体素全脑（VWWB）分析的3个主要指标。虽然这些指标的扫描仪内信度（即测试-重测信度）已经被广泛研究，但很少有研究调查它们的扫描仪间信度。在本研究中，21名健康的年轻受试者在3次访问中（V1 - V3）使用血氧水平依赖（BOLD） RS-fMRI进行扫描，V1和V2在GE MR750扫描仪上扫描，V3在Siemens Prisma上扫描。RS-fMRI数据采集在两种情况下，睁开眼睛（EO）和闭上眼睛（EC），每持续8分钟。我们首先评估了ALFF、ReHo和DC在扫描仪内和扫描仪间的可靠性。其次，我们测量了同一台扫描仪的两次扫描访问之间以及两台扫描仪之间的系统差异。第三，为了考虑扫描仪内和扫描仪间局部磁场不均匀性的电位差，我们测量了每对访问之间的相对BOLD信号强度与全脑平均BOLD信号强度的差。最后，我们使用波动幅度百分比（PerAF）来校正由相对BOLD信号强度引起的差异。扫描仪间的信度远低于扫描仪内的信度；在VWWB指标中，DC表现最差（扫描仪内和扫描仪间的比较）。PerAF与ALFF具有相似的扫描仪内可靠性，并且在所有4个指标中可靠性最好。PerAF降低了BOLD信号强度的影响，从而提高了ALFF的扫描仪间可靠性。对于多中心研究，应考虑扫描仪间的可靠性。
As the multi-center studies with resting-state functional magnetic resonance imaging (RS-fMRI) have been more and more applied to neuropsychiatric studies, both intra- and inter-scanner reliability of RS-fMRI are becoming increasingly important. The amplitude of low frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC) are 3 main RS-fMRI metrics in a way of voxel-wise whole-brain (VWWB) analysis. Although the intra-scanner reliability (i.e., test-retest reliability) of these metrics has been widely investigated, few studies has investigated their inter-scanner reliability. In the current study, 21 healthy young subjects were enrolled and scanned with blood oxygenation level dependent (BOLD) RS-fMRI in 3 visits (V1 – V3), with V1 and V2 scanned on a GE MR750 scanner and V3 on a Siemens Prisma. RS-fMRI data were collected under two conditions, eyes open (EO) and eyes closed (EC), each lasting 8 minutes. We firstly evaluated the intra- and inter-scanner reliability of ALFF, ReHo, and DC. Secondly, we measured systematic difference between two scanning visits of the same scanner as well as between two scanners. Thirdly, to account for the potential difference of intra- and inter-scanner local magnetic field inhomogeneity, we measured the difference of relative BOLD signal intensity to the mean BOLD signal intensity of the whole brain between each pair of visits. Last, we used percent amplitude of fluctuation (PerAF) to correct the difference induced by relative BOLD signal intensity. The inter-scanner reliability was much worse than intra-scanner reliability; Among the VWWB metrics, DC showed the worst (both for intra-scanner and inter-scanner comparisons). PerAF showed similar intra-scanner reliability with ALFF and the best reliability among all the 4 metrics. PerAF reduced the influence of BOLD signal intensity and hence increase the inter-scanner reliability of ALFF. For multi-center studies, inter-scanner reliability should be taken into account.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1523/jneurosci.2612-10.2010
发表时间：
2010-11-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
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通讯作者：
Milham MP
影响因子：
3.7
作者：
Song XW;Dong ZY;Long XY;Li SF;Zuo XN;Zhu CZ;He Y;Yan CG;Zang YF
通讯作者：
Zang YF
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影响因子：
3.7
作者：
Zuo, Xi-Nian;Ehmke, Ross;Milham, Michael P.
通讯作者：
Milham, Michael P.
影响因子：
5.7
作者：
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通讯作者：
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