Alloantibodies can discriminate class I major histocompatibility complex molecules associated with various endogenous peptides.
Alloantibodies can discriminate class I major histocompatibility complex molecules associated with various endogenous peptides.
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同种抗体可以区分与各种内源性肽相关的 I 类主要组织相容性复合物分子。
DOI：
10.1073/pnas.90.15.6949
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发表时间：
1993
影响因子：
11.1
通讯作者：
Bluestone,JA
中科院分区：
文献类型：
--
作者：
Sherman,LA;Chattopadhyay,S;Biggs,JA;Dick2nd,RF;Bluestone,JA
由单个主要组织相容性复合体I类基因编码的分子可以与大量肽配体中的任何一种结合。T细胞受体具有区分这些肽-I类复合物的能力，并且在许多情况下仅以足够的亲和力结合单个肽-I类复合物以触发效应子功能。相反，通常认为I类特异性同种抗体对肽的异质性无关紧要，而是针对分子上的等位基因特异性决定簇。在这份报告中，三个单克隆抗体被用来沉淀Kb分子从细胞裂解液。令人惊讶的是，在每种情况下，通过肽依赖性Kb特异性同种异体反应性溶细胞T淋巴细胞或通过生化解析检测到，发现一组不同的肽与Kb相关。这些结果表明，同种抗体的结合亲和力可受内源性肽配体的影响。
Molecules encoded by a single major histocompatibility complex class I gene can associate with any one of a large number of peptide ligands. T-cell receptors have the capacity to discriminate among these peptide-class I complexes and in many cases bind only a single peptide-class I complex with sufficient affinity to trigger effector function. In contrast, it is generally assumed that class I-specific alloantibodies are indifferent to peptide heterogeneity, being directed toward allele-specific determinants on the molecule. In this report, three monoclonal antibodies were used to precipitate Kb molecules from cell lysates. Surprisingly, in each case a different set of peptides was found to be associated with Kb as detected by peptide-dependent Kb-specific alloreactive cytolytic T lymphocytes or by biochemical resolution. These results demonstrate that the affinity of binding by alloantibodies can be affected by the endogenous peptide ligand.
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I 类限制性 T 淋巴细胞的抗原识别。
影响因子：
29.7
作者：
and A Townsend;H. Bodmer
通讯作者：
H. Bodmer
影响因子：
64.8
作者：
MURPHY, DB;LO, D;JANEWAY, CA
通讯作者：
JANEWAY, CA
影响因子：
64.8
作者：
RUDENSKY, AY;RATH, S;JANEWAY, CA
通讯作者：
JANEWAY, CA
影响因子：
15.3
作者：
ROTZSCHKE, O;FALK, K;FAATH, S;RAMMENSEE, HG
通讯作者：
RAMMENSEE, HG
感染期间产生的单克隆抗体，仅在 H-2k MHC I 类抗原的背景下识别流感血凝素的表位。
影响因子：
4.4
作者：
L. McLain;N. Dimmock
通讯作者：
N. Dimmock