Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans.
Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans.
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DOI：
10.1371/journal.pgen.1007305
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发表时间：
2018-03
期刊：
影响因子：
4.5
通讯作者：
Srinivasan S
中科院分区：
文献类型：
--
作者：
Hussey R;Littlejohn NK;Witham E;Vanstrum E;Mesgarzadeh J;Ratanpal H;Srinivasan S
The mechanisms by which the sensory environment influences metabolic homeostasis remains poorly understood. In this report, we show that oxygen, a potent environmental signal, is an important regulator of whole body lipid metabolism. C. elegans oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism under normoxia in the following way: under high oxygen and food absence, URX sensory neurons are activated, and stimulate fat loss in the intestine, the major metabolic organ for C. elegans. Under lower oxygen conditions or when food is present, the BAG sensory neurons respond by repressing the resting properties of the URX neurons. A genetic screen to identify modulators of this effect led to the identification of a BAG-neuron-specific neuropeptide called FLP-17, whose cognate receptor EGL-6 functions in URX neurons. Thus, BAG sensory neurons counterbalance the metabolic effect of tonically active URX neurons via neuropeptide communication. The combined regulatory actions of these neurons serve to precisely tune the rate and extent of fat loss to the availability of food and oxygen, and provides an interesting example of the myriad mechanisms underlying homeostatic control. We now appreciate that the sensory nervous systems of complex multicellular animals play a profound role in influencing energy balance, and body fat stores. Understanding the precise molecular mechanisms and neuroendocrine pathways by which the nervous system controls metabolic tissues has remained a tremendous challenge. Using the genetically tractable nematode C. elegans, we can dissect the critical sensory modalities that influence body fat storage and its mobilization, and their mechanisms of action. In this study, we identify the molecular mechanisms by which a salient environmental feature, oxygen, regulates the magnitude of fat loss via the counterbalancing actions of the BAG and URX oxygen sensory neurons.
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影响因子：
9.8
作者：
Chang AJ;Chronis N;Karow DS;Marletta MA;Bargmann CI
通讯作者：
Bargmann CI
影响因子：
29
作者：
Greer, Elisabeth R.;Perez, Carissa L.;Van Gilst, Marc R.;Lee, Brian H.;Ashrafi, Kaveh
通讯作者：
Ashrafi, Kaveh
影响因子：
29
作者：
Noble T;Stieglitz J;Srinivasan S
通讯作者：
Srinivasan S
影响因子：
16.2
作者：
Berwin, B;Floor, E;Martin, TFJ
通讯作者：
Martin, TFJ
DOI：
10.1016/j.cub.2015.07.037
发表时间：
2015-08-31
期刊：
Current biology : CB
影响因子：
--
作者：
Brandt JP;Ringstad N
通讯作者：
Ringstad N