THE CHALLENGES OF METABOLIC SYNDROME IN EATING DISORDERS.

THE CHALLENGES OF METABOLIC SYNDROME IN EATING DISORDERS.
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DOI:
10.3928/00485713-20200713-02
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发表时间:
2020-08
期刊:
影响因子:
0.5
通讯作者:
Pope HG Jr
Pope HG Jr
中科院分区:
医学4区
文献类型:
--
作者:
Hudson JI;Javaras KN;Pope HG Jr

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许多研究已经检查了三种主要的饮食失调症--神经性厌食症、神经性贪食症和暴食症--与代谢综合征或代谢综合征的个别组成部分(如肥胖、2型糖尿病、高血压和血脂异常)的关系。目前的证据表明,神经性厌食症不会导致代谢综合征的过度风险,并且可能与某些代谢综合征组分(包括肥胖和2型糖尿病)的风险降低有关。在一些研究中,神经性贪食症与代谢综合征风险增加有关,但在其他研究中则不然。然而,暴饮暴食与代谢综合征及其组分的风险增加密切相关-这些关联似乎不仅通过体重升高介导,而且还可能通过体重独立因素介导。鉴于暴食症是最常见的饮食失调,治疗和预防这一群体的代谢综合征是一个重大的临床和公共卫生挑战。
A number of studies have examined the association of the three major eating disorders – anorexia nervosa, bulimia nervosa, and binge-eating disorder – with metabolic syndrome, or with individual components of metabolic syndrome, such as obesity, type 2 diabetes, hypertension, and dyslipidemia. Present evidence suggests that anorexia nervosa confers no excess risk of metabolic syndrome and may be associated with lower risk of certain metabolic syndrome components, including obesity and type 2 diabetes. Bulimia nervosa shows associations with increased risk for metabolic syndrome components in some studies, but not in others. Binge-eating disorder, however, is strongly associated with increased risk for both metabolic syndrome and its components – and these associations appear to be mediated not only through elevated body weight, but also possible body-weight-independent factors. Given that binge-eating disorder is the most common eating disorder, treatment and prevention of metabolic syndrome in this group represents a significant clinical and public health challenge.
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