Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms.
Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms.
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DOI：
10.1016/j.archoralbio.2010.05.009
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发表时间：
2010-08
影响因子：
3
通讯作者：
Ebersole, Jeffery L.
中科院分区：
文献类型：
--
作者：
Huang, Chifu B.;George, Brian;Ebersole, Jeffery L.
关键词：
本研究旨在评估 omega-6、-7、-9（n-6、n-7、n-9）脂肪酸对各种口腔微生物的抗菌活性。 n-6、n-7、n-9脂肪酸，例如γ-亚油酸(GLA)、亚油酸(LA)、花生四烯酸(ARA)、棕榈油酸(PA)和油酸(OA)，其脂肪酸乙酯，GLA-EE，LA-EE，ARA-EE，PA-EE，OA-EE，及其脂肪酸甲酯，GLA-ME，LA-ME，研究了 ARA-ME、PA-ME、OA-ME 对口腔病原体变形链球菌、白色念珠菌、伴放线聚集菌、具核梭杆菌和牙龈卟啉单胞菌的抗菌活性。在 96 孔板和血琼脂板中测试了不同浓度的脂肪酸及其甲酯和乙酯对各种口腔病原体的抵抗力。将平板在37°C厌氧或需氧条件下培养48小时，并测定菌落形成单位(CFU)。数据表明，精选的 n-6、n-7、n-9 脂肪酸及其酯对这些口腔微生物表现出强大的抗菌活性，表明对个别微生物物种具有一定的特异性。 n-6、n-7、n-9脂肪酸和/或其酯的潜在用途或组合，以局部递送载体提供至口腔中的感染部位，可被视为改善口腔健康的额外治疗方法。
This study is to assess the antibacterial activity of omega-6, -7, -9 (n-6, n-7, n-9) fatty acids against various oral microorganisms. The n-6, n-7, n-9 fatty acids, such as γ-linoleic acid (GLA), linoleic acid (LA), arachidonic acid (ARA), palmitoleic acid (PA), and oleic acid (OA), their fatty acid ethyl esters, GLA-EE, LA-EE, ARA-EE, PA-EE, OA-EE, and their fatty acid methyl esters, GLA-ME, LA-ME, ARA-ME, PA-ME, OA-ME were investigated for antimicrobial activity against oral pathogens Streptococcus mutans, Candida albicans, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, and Porphyromonas gingivalis. Various concentrations of the fatty acids, their methyl and ethyl esters were tested against various oral pathogens in 96-well plates and blood-agar plate. The plates were incubated anaerobically or aerobically at 37°C for 48 hours, and the colony forming units (CFU) were determined. The data demonstrated that select n-6, n-7, n-9 fatty acids and their esters exhibited strong antimicrobial activity against these oral microorganisms, demonstrating some specificity for individual microbial species. The potential use or the combinations of the n-6, n-7, n-9 fatty acids and/or their esters, provided in a local delivery vehicle to infected sites in the oral cavity, could be considered as an additional therapeutic approach to improving oral health.
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影响因子：
3.5
作者：
Bendyk, A.;Marino, V.;Bartold, P. M.
通讯作者：
Bartold, P. M.
影响因子：
3.9
作者：
SANTOS, MJ;LOPEZJURADO, M;MATAIX, FJ
通讯作者：
MATAIX, FJ
影响因子：
4.2
作者：
Whelan, J;McEntee, MF
通讯作者：
McEntee, MF
影响因子：
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作者：
Kesavalu, L.;Bakthavatchalu, V.;Ebersole, J. L.
通讯作者：
Ebersole, J. L.
影响因子：
3.7
作者：
Huang, C. B.;Ebersole, J. L.
通讯作者：
Ebersole, J. L.