Optic nerve head biomechanics in aging and disease.
Optic nerve head biomechanics in aging and disease.
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DOI：
10.1016/j.exer.2015.02.011
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发表时间：
2015-04
影响因子：
3.4
通讯作者：
Downs, J. Crawford
中科院分区：
文献类型：
--
作者：
Downs, J. Crawford
这篇非技术评论的重点是教育读者在衰老和疾病方面的视神经头生物力学，主要有两个主题：机械力和由此产生的变形是如何在后极和ONH分布的（生物力学），以及生命系统如何对这些变形做出反应（机械生物学）。我们关注ONH作为一个结构系统是如何对IOP升高做出反应的，因为网层的急性机械反应与乳头周围巩膜、层前神经组织和层后视神经的反应相混淆。我们讨论了结缔组织、血流和细胞反应中io驱动变化的生物力学基础。我们以青光眼为主要框架来介绍ONH生物力学在衰老和疾病中的重要方面，因为ONH生物力学、衰老和后极细胞外基质（ECM）被认为是青光眼易感性、发病和进展的主要参与因素。
This nontechnical review is focused upon educating the reader on optic nerve head biomechanics in both aging and disease along two main themes: what is known about how mechanical forces and the resulting deformations are distributed in the posterior pole and ONH (biomechanics) and what is known about how the living system responds to those deformations (mechanobiology). We focus on how ONH responds to IOP elevations as a structural system, insofar as the acute mechanical response of the lamina cribrosa is confounded with the responses of the peripapillary sclera, prelaminar neural tissues, and retrolaminar optic nerve. We discuss the biomechanical basis for IOP-driven changes in connective tissues, blood flow, and cellular responses. We use glaucoma as the primary framework to present the important aspects of ONH biomechanics in aging and disease, as ONH biomechanics, aging, and the posterior pole extracellular matrix (ECM) are thought to be centrally involved in glaucoma susceptibility, onset and progression.
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影响因子：
3.5
作者：
Fazio, Massimo A.;Grytz, Rafael;Morris, Jeffrey S.;Bruno, Luigi;Gardiner, Stuart K.;Girkin, Christopher A.;Downs, J. Crawford
通讯作者：
Downs, J. Crawford
影响因子：
4.4
作者：
Cull, Grant;Burgoyne, Claude F.;Wang, Lin
通讯作者：
Wang, Lin
影响因子：
2.9
作者：
Balaratnasingam, Chandrakumar;Morgan, William H.;Yu, Dao-Yi
通讯作者：
Yu, Dao-Yi
影响因子：
3.4
作者：
Burgoyne, Claude F.
通讯作者：
Burgoyne, Claude F.
影响因子：
4.4
作者：
Downs, J. Crawford;Burgoyne, Claude F.;Sallee, Verney
通讯作者：
Sallee, Verney