Preeclampsia: multiple approaches for a multifactorial disease.
Preeclampsia: multiple approaches for a multifactorial disease.
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DOI：
10.1242/dmm.008516
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发表时间：
2012-01
影响因子：
4.3
通讯作者：
Schust DJ
中科院分区：
文献类型：
--
作者：
Pennington KA;Schlitt JM;Jackson DL;Schulz LC;Schust DJ
先兆子痫是一种妊娠特异性疾病，其特征是高血压和尿中过量蛋白排泄。它是全世界孕产妇和胎儿发病率和死亡率的一个重要原因。这种疾病几乎是人类独有的，分娩仍然是唯一有效的治疗方法。这种疾病可能是多因素的，虽然大多数先兆子痫的特点是异常母体子宫血管重塑胎儿来源的胎盘滋养层细胞。许多体外和动物模型已被用于研究先兆子痫的各个方面，最常见的是胎盘氧失调、异常滋养层侵入、不适当的母体血管损伤和异常母胎免疫相互作用的模型。对先兆子痫的病理生理学和治疗的研究继续推动这一领域的发展，尽管速度慢得令人沮丧。仍然迫切需要新的方法，新的疾病模型和创新的研究人员来有效地解决这种复杂和破坏性的疾病。
Preeclampsia is a pregnancy-specific disorder characterized by hypertension and excess protein excretion in the urine. It is an important cause of maternal and fetal morbidity and mortality worldwide. The disease is almost exclusive to humans and delivery of the pregnancy continues to be the only effective treatment. The disorder is probably multifactorial, although most cases of preeclampsia are characterized by abnormal maternal uterine vascular remodeling by fetally derived placental trophoblast cells. Numerous in vitro and animal models have been used to study aspects of preeclampsia, the most common being models of placental oxygen dysregulation, abnormal trophoblast invasion, inappropriate maternal vascular damage and anomalous maternal-fetal immune interactions. Investigations into the pathophysiology and treatment of preeclampsia continue to move the field forward, albeit at a frustratingly slow pace. There remains a pressing need for novel approaches, new disease models and innovative investigators to effectively tackle this complex and devastating disorder.
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