Controlled release of simvastatin from biomimetic β-TCP drug delivery system.
Controlled release of simvastatin from biomimetic β-TCP drug delivery system.
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DOI：
10.1371/journal.pone.0054676
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Milthorpe B
中科院分区：
文献类型：
--
作者：
Chou J;Ito T;Bishop D;Otsuka M;Ben-Nissan B;Milthorpe B
辛伐他汀已被证明可以诱导骨形成，目前迫切需要开发一种合适的给药系统来维持药物的释放，以增加治疗效果，同时减少副作用。在这项研究中，通过水热将海洋外骨骼转化为生物相容的β-磷酸三钙，研究了一种新的辛伐他汀药物释放系统。此外，辛伐他汀的释放通过添加一层外部磷灰石涂层来控制。用X射线衍射仪、傅里叶变换红外光谱、扫描电子显微镜和质谱仪对样品进行了表征，证实了转化过程。在模拟体液溶液中测定主要化学成分的体外溶出度和释放度，显示控释效果，与未包衣的样品相比，其释放量减少了约25%。本研究展示了海洋结构作为辛伐他汀药物输送系统的潜在应用。
Simvastatin have been shown to induce bone formation and there is currently a urgent need to develop an appropriate delivery system to sustain the release of the drug to increase therapeutic efficacy whilst reducing side effects. In this study, a novel drug delivery system for simvastatin by means of hydrothermally converting marine exoskeletons to biocompatible beta-tricalcium phosphate was investigated. Furthermore, the release of simvastatin was controlled by the addition of an outer apatite coating layer. The samples were characterized by x-ray diffraction analysis, fourier transform infrared spectroscopy, scanning electron microscopy and mass spectroscopy confirming the conversion process. The in-vitro dissolution of key chemical compositional elements and the release of simvastatin were measured in simulated body fluid solution showing controlled release with reduction of approximately 25% compared with un-coated samples. This study shows the potential applications of marine structures as a drug delivery system for simvastatin.
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DOI：
10.1016/s0266-4356(03)00081-0
发表时间：
2003-08-01
影响因子：
1.8
作者：
Wong, RWK;Rabie, ABM
通讯作者：
Rabie, ABM
影响因子：
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作者：
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影响因子：
56.9
作者：
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通讯作者：
Gutierrez, G
DOI：
10.1097/01.ta.0000240974.07999.bc
发表时间：
2007-07-01
影响因子：
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作者：
Kiliccoglu, Sibel Serin;Erdemli, Esra
通讯作者：
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DOI：
10.1006/bbrc.2000.2697
发表时间：
2000-05-19
影响因子：
3.1
作者：
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