Blood magnesium, and the interaction with calcium, on the risk of high-grade prostate cancer.
Blood magnesium, and the interaction with calcium, on the risk of high-grade prostate cancer.
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血液镁以及与钙的相互作用，面临着高级前列腺癌的风险。
DOI：
10.1371/journal.pone.0018237
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发表时间：
2011-04-25
期刊：
影响因子：
3.7
通讯作者：
Fowke JH
中科院分区：
文献类型：
--
作者：
Dai Q;Motley SS;Smith JA Jr;Concepcion R;Barocas D;Byerly S;Fowke JH
离子化的钙（Ca）和镁（Mg）竞争作为重要的信使来调节细胞增殖和炎症。我们假设，镁水平不足，可能相对于钙水平（例如高钙/镁比）与前列腺癌的风险更大。在这项纳什维尔男性健康研究（NMHS）的生物标志物子研究中，我们纳入了494名NMHS参与者，包括98例高级别（Gleason≥7）和100例低级别癌症病例，133例前列腺上皮内瘤变（PIN）病例和163例活检时无癌症或PIN的对照。使用线性和逻辑回归确定对照组和病例组之间血Ca、Mg和Ca/Mg比值之间的相关性，同时调整潜在的混杂因素。与对照组相比，高级别病例的血清镁水平显著较低，而钙/镁比值显著较高（分别为p= 0.04，p =0.01）。 镁升高与高级别前列腺癌的风险降低显著相关（OR = 0.26（0.09，0.85））。 Ca/Mg比值升高也与高级别前列腺癌风险增加相关（校正血清Ca和Mg后OR=2.81（1.24，6.36））。 相比之下，血中钙水平与前列腺癌或PIN无显著相关性。镁、钙或钙/镁水平与低级别癌症、PIN、PSA水平、前列腺体积或BPH治疗无关。低血镁水平和高Ca/Mg比值与高级别前列腺癌显著相关。这些发现表明镁可能通过与钙相互作用影响前列腺癌的风险。
Ionized calcium (Ca) and magnesium (Mg) compete as essential messengers to regulate cell proliferation and inflammation. We hypothesized that inadequate Mg levels, perhaps relative to Ca levels (e.g. a high Ca/Mg ratio) are associated with greater prostate cancer risk. In this biomarker sub-study of the Nashville Men's Health Study (NMHS), we included 494 NMHS participants, consisting of 98 high-grade (Gleason≥7) and 100 low-grade cancer cases, 133 prostate intraepithelial neoplasia (PIN) cases, and 163 controls without cancer or PIN at biopsy. Linear and logistic regression were used to determine associations between blood Ca, Mg, and the Ca/Mg ratio across controls and case groups while adjusting for potential confounding factors. Serum Mg levels were significantly lower, while the Ca/Mg ratio was significantly higher, among high-grade cases vs. controls (p = 0.04, p = 0.01, respectively). Elevated Mg was significantly associated with a lower risk of high-grade prostate cancer (OR = 0.26 (0.09, 0.85)). An elevated Ca/Mg ratio was also associated with an increased risk of high-grade prostate cancer (OR = 2.81 (1.24, 6.36) adjusted for serum Ca and Mg). In contrast, blood Ca levels were not significantly associated with prostate cancer or PIN.Mg, Ca, or Ca/Mg levels were not associated with low-grade cancer, PIN, PSA levels, prostate volume, or BPH treatment. Low blood Mg levels and a high Ca/Mg ratio were significantly associated with high-grade prostate cancer. These findings suggest Mg affects prostate cancer risk perhaps through interacting with Ca.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
8.8
作者：
Allen, N. E.;Key, T. J.;Appleby, P. N.;Travis, R. C.;Roddam, A. W.;Tjonneland, A.;Johnsen, N. F.;Overvad, K.;Linseisen, J.;Rohrmann, S.;Boeing, H.;Pischon, T.;Bueno-de-Mesquita, H. B.;Kiemeney, L.;Tagliabue, G.;Palli, D.;Vineis, P.;Tumino, R.;Trichopoulou, A.;Kassapa, C.;Trichopoulos, D.;Ardanaz, E.;Larranaga, N.;Tormo, M-J;Gonzalez, C. A.;Quiros, J. R.;Sanchez, M-J;Bingham, S.;Khaw, K-T;Manjer, J.;Berglund, G.;Stattin, P.;Hallmans, G.;Slimani, N.;Ferrari, P.;Rinaldi, S.;Riboli, E.
通讯作者：
Riboli, E.
影响因子：
3.8
作者：
Ahn, Jiyoung;Albanes, Demetrius;Hayes, Richard B.
通讯作者：
Hayes, Richard B.
影响因子：
5
作者：
Bussière, FI;Gueux, E;Rayssiguier, Y
通讯作者：
Rayssiguier, Y
DOI：
10.1080/07315724.2004.10719344
发表时间：
2004-02-01
影响因子：
3.5
作者：
Al-Delaimy, WK;Rimm, EB;Hu, FB
通讯作者：
Hu, FB