Anatomical network modules of the human central nervous-craniofacial skeleton system.

Anatomical network modules of the human central nervous-craniofacial skeleton system.
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DOI:
10.3389/fneur.2023.1164283
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发表时间:
2023
影响因子:
3.4
通讯作者:
--
中科院分区:
医学3区
文献类型:
--
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解剖网络分析(安娜)是一种基于网络理论的系统生物学框架,通过将模块化模型用于结构复杂性来实现解剖结构分析。人类大脑和面部结构表现出密切的结构和功能关系,暗示着共同进化的解剖网络。本研究旨在分析人类头部作为一个模块化实体,包括中枢神经系统,包括大脑,脊髓和颅面骨骼。使用来自脑、脊髓和颅面骨骼的39个解剖节点构建安娜模型。通过周围神经供应和结构之间的直接接触确定了联系。应用igraph软件中的Spinglass算法构建神经网络,识别中枢神经系统-颅面骨骼解剖网络的模块。确定了两个模块。这些包括一个前模块,其中包括前脑,前颅底,和中上部的脸,和一个后模块,其中包括中脑,后脑,下颌骨,和后颅。这些发现可能反映了驱动马赛克中枢神经系统和颅面发育的遗传和信号网络,并为颅面结构发育障碍提供了重要的系统生物学观点。
Anatomical network analysis (AnNA) is a systems biological framework based on network theory that enables anatomical structural analysis by incorporating modularity to model structural complexity. The human brain and facial structures exhibit close structural and functional relationships, suggestive of a co-evolved anatomical network. The present study aimed to analyze the human head as a modular entity that comprises the central nervous system, including the brain, spinal cord, and craniofacial skeleton. An AnNA model was built using 39 anatomical nodes from the brain, spinal cord, and craniofacial skeleton. The linkages were identified using peripheral nerve supply and direct contact between structures. The Spinglass algorithm in the igraph software was applied to construct a network and identify the modules of the central nervous system-craniofacial skeleton anatomical network. Two modules were identified. These comprised an anterior module, which included the forebrain, anterior cranial base, and upper-middle face, and a posterior module, which included the midbrain, hindbrain, mandible, and posterior cranium. These findings may reflect the genetic and signaling networks that drive the mosaic central nervous system and craniofacial development and offer important systems biology perspectives for developmental disorders of craniofacial structures.
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