Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood.
Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood.
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DOI：
10.1016/j.ajog.2014.12.038
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发表时间：
2015-04
影响因子：
9.8
通讯作者：
Chatzi, Leda
中科院分区：
文献类型：
--
作者：
Karachaliou, Marianna;Georgiou, Vaggelis;Roumeliotaki, Theano;Chalkiadaki, Georgia;Daraki, Vasiliki;Koinaki, Stella;Dermitzaki, Eirini;Sarri, Katerina;Vassilaki, Maria;Kogevinas, Manolis;Oken, Emily;Chatzi, Leda
研究孕期特异性妊娠体重增加与胎儿生长、肥胖风险和从出生到4岁的心脏代谢健康结局的关系。我们在希腊克里特岛的妊娠队列“Rhea”研究中对977对母子进行了本研究。我们测量了出生体重、6个月至4岁的体重指数、腰围、皮褶厚度、血压、血脂、c反应蛋白和4岁时的脂肪组织激素水平。我们分别使用多元线性和对数泊松回归模型来检验暴露与连续或二元结果的关系。妊娠前三个月的妊娠体重增加率（每200克/周）与2岁至4岁期间超重/肥胖风险增加相关[RR: 1.25, (95% CI: 1.09, 1.42)]，但与出生尺寸无关。妊娠前三个月体重每增加200克/周也与高腰围[RR: 1.13, (95% CI: 1.04, 1.23)]、高皮褶厚度[RR: 1.15 (95% CI: 1.02, 1.29)]和4岁时舒张压升高的风险相关[β: 0.43 mmHg (95% CI: 0.00, 0.86)]。妊娠中期和晚期妊娠体重增加率（每200克/周）越大，胎龄新生儿患肥胖的风险越大[RR: 1.22, (95% CI: 1.02, 1.45)]，脐带血瘦素水平越高[几何均值之比：1.08 (95% CI: 1.00, 1.17)]，但与后期儿童人体测量值无关。妊娠期体重增加的时间可能会对儿童心脏代谢结果产生不同的影响。
To investigate the association of trimester-specific gestational weight gain with offspring fetal growth, obesity risk, and cardio-metabolic health outcomes from birth up to 4 years of age. We conducted the present study in 977 mother-child pairs of the pregnancy cohort “Rhea” study in Crete, Greece. We measured birth weight, body mass index from 6 months to 4 years of age, waist circumference, skinfold thickness, blood pressure, and blood levels of lipids, C-reactive protein, and adipose tissue hormones at 4 years of age. We used multiple linear and log Poisson regression models to examine the association of exposure with continuous or binary outcomes respectively. Greater rate of gestational weight gain in the first trimester of pregnancy (per 200 g/week) was associated with increased risk of overweight/obesity from 2 years [RR: 1.25, (95% CI: 1.09, 1.42)] to 4 years of age [RR: 1.15, (95% CI: 1.05, 1.25)], but not with birth size. Each 200 gr/week of weight gain in the first trimester of pregnancy was also associated with greater risk of high waist circumference [RR: 1.13, (95% CI: 1.04, 1.23)], high sum of skinfold thickness [RR: 1.15 (95% CI: 1.02, 1.29)] and higher diastolic blood pressure at 4 years of age [β: 0.43 mmHg (95% CI: 0.00, 0.86)]. Greater rate of gestational weight gain during the second and third trimesters of pregnancy (per 200 gr/week) was associated with greater risk of large for gestational age neonates [RR: 1.22, (95% CI: 1.02, 1.45)] and higher levels of cord blood leptin [ratio of geometric means: 1.08 (95% CI: 1.00, 1.17)], but not with child anthropometry at later ages. Timing of gestational weight gain may differentially influence childhood cardio-metabolic outcomes.
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发表时间：
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期刊：
Diabetes, obesity & metabolism
影响因子：
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作者：
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影响因子：
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发表时间：
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期刊：
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影响因子：
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