Modification of the surface nanotopography of implant devices: A translational perspective.
Modification of the surface nanotopography of implant devices: A translational perspective.
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DOI：
10.1016/j.mtbio.2021.100152
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Fernandez A
中科院分区：
文献类型：
--
作者：
Harawaza K;Cousins B;Roach P;Fernandez A
对开发上级、安全和更复杂的植入物的需求日益增加，特别是在我们的社会历史上一直在朝着人口日益老龄化的方向发展的情况下。目前，大多数研究都集中在下一代先进的医疗植入物上，这些植入物不仅具有生物相容性，而且具有在细胞水平上指导特异性免疫调节的改性表面。虽然有大量关于细胞表面相互作用以及如何在研究水平上纳米制造表面的信息，但对学术知识如何转化为临床试验和商业技术知之甚少。在这篇综述中，我们提供了一个临床翻译的角度来看，使用受控的物理表面改性的医疗植入物，提出了从临床试验和商业产品获得的数据分析。我们还评估了最先进的纳米纤维技术，正在应用于种植体表面改性在临床水平。最后，我们确定了该领域目前面临的一些挑战，包括需要更先进的纳米图案化技术，临床试验数量相对较少，并对未来成功临床翻译的途径进行了探讨。
There is an increasing need for the development of superior, safe, and more sophisticated implants, especially as our society historically has been moving towards an increasingly aging population. Currently, most research is being focused on the next generation of advanced medical implants, that are not only biocompatible but have modified surfaces that direct specific immunomodulation at cellular level. While there is a plethora of information on cell-surface interaction and how surfaces can be nanofabricated at research level, less is known about how the academic knowledge has been translated into clinical trials and commercial technologies. In this review, we provide a clinical translational perspective on the use of controlled physical surface modification of medical implants, presenting an analysis of data acquired from clinical trials and commercial products. We also evaluate the state-of-the-art of nanofabrication techniques that are being applied for implant surface modification at a clinical level. Finally, we identify some current challenges in the field, including the need of more advanced nanopatterning techniques, the comparatively small number of clinical trials and comment on future avenues to be explored for a successful clinical translation.
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