Pre-chemotherapy differences in visuospatial working memory in breast cancer patients compared to controls: an FMRI study.
Pre-chemotherapy differences in visuospatial working memory in breast cancer patients compared to controls: an FMRI study.
复制标题
DOI：
10.3389/fnhum.2011.00122
复制
发表时间：
2011
影响因子：
2.9
通讯作者：
Smith A
中科院分区：
文献类型：
--
作者：
Scherling C;Collins B;Mackenzie J;Bielajew C;Smith A
简介：认知缺陷是化疗的副作用，但治疗前的研究是有限的。本研究探讨了乳腺癌（BC）患者和对照组在化疗前工作记忆过程中的神经功能差异。方法：早期乳腺癌女性（23例），手术后但化疗前扫描，单独匹配非癌症对照。参与者在执行视觉空间N-back任务的同时进行功能性磁共振成像（fMRI），并通过多组比较分析数据。功能磁共振成像任务表现，神经心理学测试，医院记录，唾液生物标志物也被收集。结果：在神经心理学测试、雌激素或皮质醇方面没有显著的组间差异。患者的佣金错误显着减少，但整体正确的反应较少，在任务过程中比对照组慢。功能磁共振成像数据的组间差异显著，但结果取决于分析的类型。与对照组相比，BC患者在工作记忆中的额下回、前额叶、丘脑和中脑等区域的激活增加。个别群体回归显示大脑活动和佣金错误之间的反向关系。结论：这是第一个功能磁共振成像研究，以揭示BC患者化疗前和对照组之间的视觉空间工作记忆的神经生理差异。这些结果也增加了对BC及其相关因素对工作记忆网络影响的认识。意义：这突出了需要更好地了解化疗前BC患者和相关混杂变量的影响。
Introduction: Cognitive deficits are a side-effect of chemotherapy, however pre-treatment research is limited. This study examines neurofunctional differences during working memory between breast cancer (BC) patients and controls, prior to chemotherapy. Methods: Early stage BC females (23), scanned after surgery but before chemotherapy, were individually matched to non-cancer controls. Participants underwent functional magnetic resonance imaging (fMRI) while performing a Visuospatial N-back task and data was analyzed by multiple group comparisons. fMRI task performance, neuropsychological tests, hospital records, and salivary biomarkers were also collected. Results: There were no significant group differences on neuropsychological tests, estrogen, or cortisol. Patients made significantly fewer commission errors but had less overall correct responses and were slower than controls during the task. Significant group differences were observed for the fMRI data, yet results depended on the type of analysis. BC patients presented with increased activations during working memory compared to controls in areas such as the inferior frontal gyrus, insula, thalamus, and midbrain. Individual group regressions revealed a reverse relationship between brain activity and commission errors. Conclusion: This is the first fMRI investigation to reveal neurophysiological differences during visuospatial working memory between BC patients pre-chemotherapy and controls. These results also increase the knowledge about the effects of BC and related factors on the working memory network. Significance: This highlights the need to better understand the pre-chemotherapy BC patient and the effects of associated confounding variables.
登录
查看更多内容
影响因子：
3.7
作者：
Carlson, S;Martinkauppi, S;Aronen, HJ
通讯作者：
Aronen, HJ
影响因子：
45.3
作者：
Ahles, TA;Saykin, AJ;Silberfarb, PM
通讯作者：
Silberfarb, PM
影响因子：
45.3
作者：
Ahles, TA;Tope, DM;Mills, L
通讯作者：
Mills, L
影响因子：
8.4
作者：
BERGLUND, G;BOLUND, C;SJODEN, PO
通讯作者：
SJODEN, PO
影响因子：
5.3
作者：
Aron, Adam R.;Behrens, Tim E.;Poldrack, Russell A.
通讯作者：
Poldrack, Russell A.