Moving beyond energy homeostasis: new roles for glucagon-like peptide-1 in food and drug reward.
Moving beyond energy homeostasis: new roles for glucagon-like peptide-1 in food and drug reward.
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DOI：
10.1016/j.neuint.2013.10.003
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发表时间：
2014-07
影响因子：
4.2
通讯作者：
Galli A
中科院分区：
文献类型：
--
作者：
Reddy IA;Stanwood GD;Galli A
胰高血糖素样肽-1（GLP-1）是一种激素和神经肽，已知部分通过控制食物摄入的中心作用来调节能量稳态。历史上，这种中心作用主要归因于脑干和下丘脑中的GLP-1受体信号传导。然而，新的数据表明，GLP-1也有助于非稳态调节食物奖励和动机行为的大脑奖励中心，包括腹侧被盖区和丘脑核。GLP-1信号调节奖赏回路的假设为证明GLP-1减弱对精神兴奋剂和酒精的奖赏的研究提供了动力。在这里，我们研究了GLP-1介导的食物和药物奖励调节的现有证据，并使用这些发现来假设大脑奖励中心内的作用机制。
Glucagon-like peptide-1 (GLP-1), a hormone and neuropeptide, is known to regulate energy homeostasis in part through an established central role in controlling food intake. Historically this central role has largely been attributed to GLP-1 receptor signaling in the brainstem and hypothalamus. However, emerging data indicate that GLP-1 also contributes to non-homeostatic regulation of food reward and motivated behaviors in brain reward centers, including the ventral tegmental area and nucleus accumbens. The hypothesis that GLP-1 signaling modulates reward circuitry has provided the impetus for studies demonstrating that GLP-1 attenuates reward for psychostimulants and alcohol. Here, we examine current evidence for GLP-1-mediated regulation of food and drug reward and use these findings to hypothesize mechanisms of action within brain reward centers.
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DOI：
10.1523/jneurosci.3262-11.2011
发表时间：
2011-10-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dossat AM;Lilly N;Kay K;Williams DL
通讯作者：
Williams DL
影响因子：
2.9
作者：
Davis, Jon F.;Tracy, Andrea L.;Schurdak, Jennifer D.;Magrisso, Irwin J.;Grayson, Bernadette E.;Seeley, Randy J.;Benoit, Stephen C.
通讯作者：
Benoit, Stephen C.
影响因子：
3.4
作者：
COMER, SD;LAC, ST;CARROLL, ME
通讯作者：
CARROLL, ME
影响因子：
10.6
作者：
Davis, Jon F.;Schurdak, Jennifer D.;Benoit, Stephen C.
通讯作者：
Benoit, Stephen C.
影响因子：
2.9
作者：
Abbott, CR;Monteiro, M;Bloom, SR
通讯作者：
Bloom, SR