Development of functional organization within the sensorimotor network across the perinatal period.
Development of functional organization within the sensorimotor network across the perinatal period.
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DOI：
10.1002/hbm.25785
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发表时间：
2022-05
影响因子：
4.8
通讯作者：
Muceli S
中科院分区：
文献类型：
--
作者：
Dall'Orso S;Arichi T;Fitzgibbon SP;Edwards AD;Burdet E;Muceli S
在成熟的人类大脑中，与不同身体部位相关的神经处理反映在功能连接的模式中，这在相对皮质半球的功能同源物之间是最强的。为了了解这种组织是如何首先建立的，我们研究了400名早产儿和足月儿的感觉运动皮层中肢体区域之间的功能连接，这些婴儿的年龄相当于妊娠晚期（月经后32 - 45周）。从独立数据集的新生儿中根据经验得出的功能反应获得面具。我们证明了早期存在一个粗糙但空间组织的功能连接，在早产期间迅速成熟，在正常出生时达到成人样配置。具体来说，同源区域之间的连接性最强，其次是早产儿大脑中相邻区域（不同肢体但相同半球）之间的连接性，并随着年龄的增长而增加。这些变化是特定的感觉运动网络。至关重要的是，这些轨迹强烈依赖于年龄而不是出生年龄。这表明，在围产期期间，感觉运动皮层经历了预先编程的变化，决定了在没有脑损伤的情况下早产不会改变的功能运动组织。为了研究人类大脑感觉运动组织内的典型发育轨迹，我们在一个独特的高质量静息状态功能性MRI大型数据集中描述了身体区域表示之间连接性的成熟变化，该数据集来自400名新生儿，年龄与妊娠晚期相当。我们的研究结果表明，在感觉运动网络中，早期存在一个粗糙的功能组织，它迅速成熟，在正常出生时达到成人样的配置。通过比较早产儿和足月出生的婴儿，我们进一步证明，这种成熟的轨迹是强烈驱动的预编程机制，并没有显着改变环境因素。
In the mature human brain, the neural processing related to different body parts is reflected in patterns of functional connectivity, which is strongest between functional homologs in opposite cortical hemispheres. To understand how this organization is first established, we investigated functional connectivity between limb regions in the sensorimotor cortex in 400 preterm and term infants aged across the equivalent period to the third trimester of gestation (32–45 weeks postmenstrual age). Masks were obtained from empirically derived functional responses in neonates from an independent data set. We demonstrate the early presence of a crude but spatially organized functional connectivity, that rapidly matures across the preterm period to achieve an adult‐like configuration by the normal time of birth. Specifically, connectivity was strongest between homolog regions, followed by connectivity between adjacent regions (different limbs but same hemisphere) already in the preterm brain, and increased with age. These changes were specific to the sensorimotor network. Crucially, these trajectories were strongly dependent on age more than age of birth. This demonstrates that during the perinatal period the sensorimotor cortex undergoes preprogrammed changes determining the functional movement organization that are not altered by preterm birth in absence of brain injury. To study the typical trajectory of development within the human brain's sensorimotor organization, we characterized maturational changes in connectivity between body region representations in a unique large dataset of high‐quality resting‐state functional MRI from 400 neonates aged across the equivalent period to the third trimester of gestation. Our results demonstrate the early presence of a crude functional organization within the sensorimotor network, that rapidly matures to achieve an adult‐like configuration by the normal time of birth. Through comparison between preterm and term born infants, we further demonstrate that this maturation trajectory is strongly driven by preprogrammed mechanisms and is not significantly altered by environmental factors.
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DOI：
10.1093/cercor/bhy050
发表时间：
2018-07-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Dall'Orso S;Steinweg J;Allievi AG;Edwards AD;Burdet E;Arichi T
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影响因子：
5.7
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Counsell SJ
影响因子：
5.7
作者：
Agcaoglu O;Miller R;Mayer AR;Hugdahl K;Calhoun VD
通讯作者：
Calhoun VD
影响因子：
3.7
作者：
Fransson, Peter;Aden, Ulrika;Lagercrantz, Hugo
通讯作者：
Lagercrantz, Hugo
DOI：
10.1093/cercor/bhv203
发表时间：
2016-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Allievi AG;Arichi T;Tusor N;Kimpton J;Arulkumaran S;Counsell SJ;Edwards AD;Burdet E
通讯作者：
Burdet E