Ergogenic effects of quercetin supplementation in trained rats.
Ergogenic effects of quercetin supplementation in trained rats.
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DOI：
10.1186/1550-2783-10-3
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发表时间：
2013-01-14
影响因子：
5.1
通讯作者：
Aranda P
中科院分区：
文献类型：
--
作者：
Casuso RA;Martínez-Amat A;Martínez-López EJ;Camiletti-Moirón D;Porres JM;Aranda P
槲皮素是一种天然多酚类化合物，目前正在研究其提高线粒体生物合成的能力。久坐不动的小鼠表现出更高的耐力，但在人类模型中的结果是矛盾的。我们在啮齿动物模型中研究了六周耐力训练和槲皮素补充对耐力表现和训练标志物的影响。将大鼠随机分为以下组之一：安慰剂+久坐（PS）、槲皮素+久坐（QS）、安慰剂+耐力训练（PT）和槲皮素+耐力训练（QT）。隔日以25 mg/kg的剂量给予槲皮素。在6周的治疗期间，记录训练的容量参数，6周后，所有组进行最大分级VO 2 max测试和低强度耐力跑步疲劳测试。在低强度试验中，VO 2峰值（p>0.999）和长跑均无影响，尽管QT间期较PT间期高14%（P = 0.097）。与PT（p=0.023）相比，QT运动后血乳酸增加，与PS（p=0.024）相比，QS运动后血乳酸也增加。这项研究表明，在训练大鼠中，与安慰剂相比，补充槲皮素6周后，对VO 2峰值、VO 2峰值时的速度或疲劳耐力时间没有影响。槲皮素被证明可以增加高强度运动后血乳酸的产生。
Quercetin is a natural polyphenolic compound currently under study for its ergogenic capacity to improve mitochondrial biogenesis. Sedentary mice have exhibited increased endurance performance, but results are contradictory in human models. We examined the effects of six weeks of endurance training and quercetin supplementation on markers of endurance performance and training in a rodent model. Rats were randomly assigned to one of the following groups: placebo+sedentary (PS), quercetin+sedentary (QS), placebo+endurance training (PT) and quercetin+endurance training (QT). Quercetin was administered at a dose of 25 mg/kg on alternate days. During six weeks of treatment volume parameters of training were recorded, and after six weeks all groups performed a maximal graded VO2 max test and a low-intensity endurance run-to-fatigue test. No effects were found in VO2 peak (p>0.999), nor in distance run during low-intensity test, although it was 14% greater in QT when compared with PT (P = 0.097). Post-exercise blood lactate was increased in QT when compared with PT (p=0.023) and also in QS compared with PS (p=0.024). This study showed no effects in VO2 peak, speed at VO2 peak or endurance time to exhaustion after six weeks of quercetin supplementation compared with placebo in trained rats. Quercetin was show to increase blood lactate production after high-intensity exercise.
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影响因子：
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