First complete genome sequence of parainfluenza virus 5 isolated from lesser panda.

First complete genome sequence of parainfluenza virus 5 isolated from lesser panda.
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DOI:
10.1007/s00705-017-3245-0
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发表时间:
2017-05
影响因子:
2.7
通讯作者:
Luo ML
Luo ML
中科院分区:
医学4区
文献类型:
--
作者:
Zhai JQ;Zhai SL;Lin T;Liu JK;Wang HX;Li B;Zhang H;Zou SZ;Zhou X;Wu MF;Chen W;Luo ML

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副流感病毒5型(PIV 5)在哺乳动物和人类中广泛传播。到目前为止,关于小熊猫感染PIV 5的信息很少。本研究从广州动物园一只患有呼吸道疾病的小熊猫体内分离到一株PIV 5变异株(命名为ZJQ-221)。发现ZJQ-221的全长基因组为15,246个核苷酸,并且由编码八种蛋白质的七个非重叠基因组成(即,NP、V、P、M、F、SH、HN和L)。序列比对和遗传分析表明,ZJQ-221与来自韩国的犬源PIV 5株(1168-1)具有密切的亲缘关系。本研究结果证实了小熊猫体内存在PIV 5,并表明这种哺乳动物可能是一种天然宿主。此外,他们强调迫切需要加强病毒监测和动物园动物中的PIV 5控制。本文的在线版本(doi:10.1007/s 00705 -017-3245-0)包含补充材料,可供授权用户使用。
Parainfluenza virus 5 (PIV5) is widespread in mammals and humans. Up to now, there is little information about PIV5 infection in lesser pandas. In this study, a PIV5 variant (named ZJQ-221) was isolated from a lesser panda with respiratory disease in Guangzhou zoo in Guangdong province, southern China. The full-length genome of ZJQ-221 was found to be 15,246 nucleotides and consisted of seven non-overlapping genes encoding eight proteins (i.e., NP, V, P, M, F, SH, HN and L). Sequence alignment and genetic analysis revealed that ZJQ-221 shared a close relationship with a PIV5 strain of canine-origin (1168-1) from South Korea. The findings of this study confirm the presence of PIV5 in lesser panda and indicate this mammal as a possible natural reservoir. Furthermore they highlight the urgent need to strengthen viral surveillance and control of PIV5 in zoo animals. The online version of this article (doi:10.1007/s00705-017-3245-0) contains supplementary material, which is available to authorized users.
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