Extraction, Preconcentration and Isolation of Flavonoids from Apocynum venetum L. Leaves Using Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with an Aqueous Biphasic System.
Extraction, Preconcentration and Isolation of Flavonoids from Apocynum venetum L. Leaves Using Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with an Aqueous Biphasic System.
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使用基于离子液体的超声辅助萃取结合水双相系统从罗布麻叶中提取、富集和分离黄酮类化合物
DOI：
10.3390/molecules21030262
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发表时间：
2016-03-04
期刊：
影响因子：
--
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Tan Z;Yi Y;Wang H;Zhou W;Wang C
背景：离子液体被认为是一种绿色溶剂，广泛应用于各种化合物的萃取。方法：以罗布麻叶中黄酮类化合物为研究对象。超声波辅助提取（UAE）。对几个主要影响因素进行了优化。然后，应用双水相系统（ABS）进一步分离黄酮类化合物。结果：黄酮类化合物主要分布在顶相中，杂质被萃取到底相中。详细研究了影响提取的参数，即盐的类型和浓度、温度和pH。在最佳条件下（72.43% IL提取液，28.57%（NH4）2SO4，25 °C，pH4.5），富集因子和萃取效率分别为3.78%和93.35%。结论：这种简单有效的方法有望在药用植物资源中药物活性成分的提取和分离中得到广泛应用。
Background: Ionic liquids (ILs) are considered as green solvents, and widely applied for the extraction of various compounds. Methods: The present research focuses on the extraction of flavonoids from Apocynum venetum L. leaves by ultrasound-assisted extraction (UAE). Several major influencing factors were optimized. Then, an aqueous biphasic system (ABS) was applied for further isolation of flavonoids. Results: The flavonoids were mainly distributed in the top phase, while impurities were extracted to the bottom phase. The parameters influencing the extraction, namely type and concentration of salt, temperature, and pH, were studied in detail. Under optimized conditions (72.43% IL extract, 28.57% (NH4)2SO4, 25 °C temperature, pH 4.5), the preconcentration factor and extraction efficiency were found to be 3.78% and 93.35%, respectively. Conclusions: This simple and efficient methodology is expected to see great use in the extraction and isolation of pharmaceutically active components from medicinal plant resources.
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作者：
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