Lateral competition for cortical space by layer-specific horizontal circuits.
Lateral competition for cortical space by layer-specific horizontal circuits.
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大脑皮层通过整合感觉环境的不同特征，构建了一个连贯的世界表征。虽然这些特征是跨皮质层垂直处理的，但相互连接相邻皮质区域的水平投影允许以上下文相关的方式处理这些特征。尽管有丰富的生理学和心理物理学研究探讨水平投射的功能，但它们如何协调大脑皮层区域之间的活动仍然知之甚少。我们通过选择性地激活小鼠躯体感觉皮质中的水平投射神经元来解决这个问题，并确定了由此产生的兴奋和抑制的空间模式如何影响皮质活动。我们发现，水平投射抑制了浅层，同时激活了较深的皮质输出层。这种特定于层的调制不是由于激发和抑制的空间分离，而是由于这两个相对的电导之间的特定于层的比率。通过这种机制，皮质区域利用水平投射来争夺皮质空间。
The cerebral cortex constructs a coherent representation of the world by integrating distinct features of the sensory environment. Although these features are processed vertically across cortical layers, horizontal projections interconnecting neighbouring cortical domains allow these features to be processed in a context-dependent manner. Despite the wealth of physiological and psychophysical studies addressing the function of horizontal projections, how they coordinate activity among cortical domains remains poorly understood. We addressed this question by selectively activating horizontal projection neurons in mouse somatosensory cortex, and determined how the resulting spatial pattern of excitation and inhibition affects cortical activity. We found that horizontal projections suppress superficial layers while simultaneously activating deeper cortical output layers. This layer-specific modulation does not result from a spatial separation of excitation and inhibition, but from a layer-specific ratio between these two opposing conductances. Through this mechanism, cortical domains exploit horizontal projections to compete for cortical space.
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影响因子：
25
作者：
Kampa, Bjorn M.;Letzkus, Johannes J.;Stuart, Greg J.
通讯作者：
Stuart, Greg J.
影响因子：
16.2
作者：
Lefort, Sandrine;Tomm, Christian;Petersen, Carl C. H.
通讯作者：
Petersen, Carl C. H.
影响因子：
25
作者：
Boyden, ES;Zhang, F;Deisseroth, K
通讯作者：
Deisseroth, K
影响因子：
34.7
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Ascoli, Giorgio A.;Alonso-Nanclares, Lidia;Anderson, Stewart A.;Barrionuevo, German;Benavides-Piccione, Ruth;Burkhalter, Andreas;Buzsaki, Gyoergy;Cauli, Bruno;DeFelipe, Javier;Fairen, Alfonso;Feldmeyer, Dirk;Fishell, Gord;Fregnac, Yves;Freund, Tamas F.;Gardner, Daniel;Gardner, Esther P.;Goldberg, Jesse H.;Helmstaedter, Moritz;Hestrin, Shaul;Karube, Fuyuki;Kisvarday, Zoltan F.;Lambolez, Bertrand;Lewis, David A.;Marin, Oscar;Markram, Henry;Munoz, Alberto;Packer, Adam;Petersen, Carl C. H.;Rockland, Kathleen S.;Rossier, Jean;Rudy, Bernardo;Somogyi, Peter;Staiger, Jochen F.;Tamas, Gabor;Thomson, Alex M.;Toledo-Rodriguez, Maria;Wang, Yun;West, David C.;Yuste, Rafael
通讯作者：
Yuste, Rafael
影响因子：
3.3
作者：
AGMON, A;CONNORS, BW
通讯作者：
CONNORS, BW