An engaged research study to assess the effect of a 'real-world' dietary intervention on urinary bisphenol A (BPA) levels in teenagers.
An engaged research study to assess the effect of a 'real-world' dietary intervention on urinary bisphenol A (BPA) levels in teenagers.
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DOI：
10.1136/bmjopen-2017-018742
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发表时间：
2018-02-03
期刊：
影响因子：
2.9
通讯作者：
Harries LW
中科院分区：
文献类型：
--
作者：
Galloway TS;Baglin N;Lee BP;Kocur AL;Shepherd MH;Steele AM;BPA Schools Study Consortium;Harries LW
双酚 A (BPA) 与不良的人类健康结果有关，这种化合物的接触在西方世界几乎无处不在。我们的目的是研究是否可以通过在现实环境中改变饮食来自我调节 BPA 暴露。一项参与研究饮食干预研究由来自六所学校的健康青少年设计、实施和分析，并在他们自己的家中进行。来自英国西南部学校的总共 94 名 17 岁至 19 岁的学生提供了饮食日记和尿液样本进行分析。研究人员参与者设计了一套基于文献的指南，用于减少饮食中 BPA 的含量，并遵循 7 天。在干预前后测量肌酐调整后的尿 BPA 水平。有关包装和摄入的食物/饮料的信息用于计算预期接触的 BPA 风险评分。进行了定性分析，以确定解决饮食长期可持续性的主题。基线时，86% 的参与者尿液中检测到 BPA，中值为 1.22 ng/mL (IQR 1.99)。总体而言，干预饮食对 BPA 水平没有影响 (P=0.25)，但干预后尿 BPA 浓度下降的参与者与其初始 BPA 水平呈正相关 (P=0.003)。定性分析确定了有关生活方式限制感和当前标签实践不足的主题。在这项自我干预研究中，我们没有发现任何证据表明在现实环境中可以通过饮食来调节 BPA 暴露。此外，我们的研究参与者表示，由于很难识别不含 BPA 的食物，他们不太可能长期维持这种饮食。
Bisphenol A (BPA) has been associated with adverse human health outcomes and exposure to this compound is near-ubiquitous in the Western world. We aimed to examine whether self-moderation of BPA exposure is possible by altering diet in a real-world setting. An Engaged Research dietary intervention study designed, implemented and analysed by healthy teenagers from six schools and undertaken in their own homes. A total of 94 students aged between 17 and 19 years from schools in the South West of the UK provided diet diaries and urine samples for analysis. Researcher participants designed a set of literature-informed guidelines for the reduction of dietary BPA to be followed for 7 days. Creatinine-adjusted urinary BPA levels were taken before and after the intervention. Information on packaging and food/drink ingested was used to calculate a BPA risk score for anticipated exposure. A qualitative analysis was carried out to identify themes addressing long-term sustainability of the diet. BPA was detected in urine of 86% of participants at baseline at a median value of 1.22 ng/mL (IQR 1.99). No effect of the intervention diet on BPA levels was identified overall (P=0.25), but there was a positive association in those participants who showed a drop in urinary BPA concentration postintervention and their initial BPA level (P=0.003). Qualitative analysis identified themes around feelings of lifestyle restriction and the inadequacy of current labelling practices. We found no evidence in this self-administered intervention study that it was possible to moderate BPA exposure by diet in a real-world setting. Furthermore, our study participants indicated that they would be unlikely to sustain such a diet long term, due to the difficulty in identifying BPA-free foods.
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DOI：
10.1038/nrendo.2016.186
发表时间：
2017-03
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Braun JM
通讯作者：
Braun JM
影响因子：
10.4
作者：
Rudel RA;Gray JM;Engel CL;Rawsthorne TW;Dodson RE;Ackerman JM;Rizzo J;Nudelman JL;Brody JG
通讯作者：
Brody JG
影响因子：
10.4
作者：
Zota AR;Phillips CA;Mitro SD
通讯作者：
Mitro SD
影响因子：
3.7
作者：
Melzer D;Rice NE;Lewis C;Henley WE;Galloway TS
通讯作者：
Galloway TS
DOI：
10.1080/0265203031000119061
发表时间：
2003-07-01
期刊：
FOOD ADDITIVES AND CONTAMINANTS
影响因子：
--
作者：
Brede, C;Fjeldal, P;Herikstad, H
通讯作者：
Herikstad, H