Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.
Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06.
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DOI：
10.1371/journal.pone.0008673
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发表时间：
2010-01-13
期刊：
影响因子：
3.7
通讯作者：
Galloway TS
中科院分区：
文献类型：
--
作者：
Melzer D;Rice NE;Lewis C;Henley WE;Galloway TS
双酚A（BPA）是一种高产量的化学品，广泛用于食品和饮料包装。在2003/04年国家健康和营养检查调查（NHANES）的成年参与者中，尿BPA浓度与心脏病、糖尿病和肝酶之间的关系此前已有报道。我们的目的是评估2005/06年NHANES中尿BPA浓度和健康指标之间的关联，以及收集年份的汇总数据。NHANES的横断面分析：受试者为n = 1455（2003/04）和n = 1493（2005/06）例18-74岁的成年人，代表美国的一般成年人群。 回归模型根据年龄、性别、种族/民族、教育、收入、吸烟、BMI、腰围和尿肌酐浓度进行调整。主要结果是报告心脏病发作、冠心病、心绞痛和糖尿病的诊断和血清肝酶水平。2005/06年的尿BPA浓度（几何平均值1.79 ng/ml，95% CI：1.64 - 1.96）低于2003/04年（2.49 ng/ml，CI：2.20 - 2.83，差异p值= 0.00002）。 在2005/06年（BPA每z分数增加的OR = 1.33，95%CI：1.01至1.75，p = 0.043）和汇总数据（OR = 1.42，CI：1.17至1.72，p = 0.001）中，较高的BPA浓度与冠心病相关。 与糖尿病的关联在2005/06年没有达到显著性，但汇总估计值仍然显著（OR = 1.24，CI：1.10至1.40，p = 0.001）。 与γ-谷氨酰转移酶浓度没有总体相关性，但与碱性磷酸酶和乳酸脱氢酶的合并相关性仍然显著。较高的BPA暴露，反映在较高的BPA尿浓度，是一贯与报告的心脏病在美国的一般成年人口。迫切需要进行研究，以澄清这些协会的机制。
Bisphenol A (BPA) is a high production volume chemical widely used in food and drinks packaging. Associations have previously been reported between urinary BPA concentrations and heart disease, diabetes and liver enzymes in adult participants of the National Health and Nutrition Examination Survey (NHANES) 2003/04. We aimed to estimate associations between urinary BPA concentrations and health measures in NHANES 2005/06 and in data pooled across collection years. A cross-sectional analysis of NHANES: subjects were n = 1455 (2003/04) and n = 1493 (2005/06) adults aged 18–74 years, representative of the general adult population of the United States. Regression models were adjusted for age, sex, race/ethnicity, education, income, smoking, BMI, waist circumference, and urinary creatinine concentration. Main outcomes were reported diagnoses of heart attack, coronary heart disease, angina and diabetes and serum liver enzyme levels. Urinary BPA concentrations in 2005/06 (geometric mean 1.79 ng/ml, 95% CI: 1.64 to 1.96) were lower than in 2003/04 (2.49 ng/ml, CI: 2.20 to 2.83, difference p-value = 0.00002). Higher BPA concentrations were associated with coronary heart disease in 2005/06 (OR per z-score increase in BPA = 1.33, 95%CI: 1.01 to 1.75, p = 0.043) and in pooled data (OR = 1.42, CI: 1.17 to 1.72, p = 0.001). Associations with diabetes did not reach significance in 2005/06, but pooled estimates remained significant (OR = 1.24, CI: 1.10 to 1.40, p = 0.001). There was no overall association with gamma glutamyl transferase concentrations, but pooled associations with alkaline phosphatase and lactate dehydrogenase remained significant. Higher BPA exposure, reflected in higher urinary concentrations of BPA, is consistently associated with reported heart disease in the general adult population of the USA. Studies to clarify the mechanisms of these associations are urgently needed.
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影响因子：
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作者：
Newbold, Retha R.;Padilla-Banks, Elizabeth;Heindel, Jerrold J.
通讯作者：
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DOI：
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发表时间：
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影响因子：
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