Interaction between decision-making and interoceptive representations of bodily arousal in frontal cortex.
Interaction between decision-making and interoceptive representations of bodily arousal in frontal cortex.
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DOI：
10.1073/pnas.2014781118
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发表时间：
2021-08-31
影响因子：
11.1
通讯作者：
Rudebeck PH
中科院分区：
文献类型：
--
作者：
Fujimoto A;Murray EA;Rudebeck PH
身体唤醒状态如何影响决策一直是心理学的核心问题，但其神经机制尚不清楚。我们记录了心率（HR），这是衡量身体唤醒程度的指标，同时监测猕猴眶额皮质（OFC）和背侧前扣带皮层（dACC）的神经活动，以做出奖励引导的决策。在完整的猕猴中，较高的心率与较短的反应时间相关。同时，OFC 和 dACC 中一组神经元的活动选择性地编码 HR。杏仁核损伤后，心率普遍增加，现在心率和反应时间之间的关系发生了改变。在神经水平上，dACC 中的编码平衡转向 HR 信号，这表明身体唤醒影响决策的特定机制。决策和唤醒的表征密切相关。行为研究经典地表明，身体唤起太少或太多都不利于决策，这表明身体唤起和表现之间存在倒“U”关系。这些过程如何在单个神经元以及所涉及的神经回路水平上相互作用尚不清楚。在这里，我们记录了猕猴做出奖励引导决策时眶额皮层（OFC）和背侧前扣带皮层（dACC）的神经活动。心率（HR）也被记录并用作身体唤醒的指标。在受试者接受双侧杏仁核兴奋性毒性损伤之前和之后进行记录。在完整的猴子中，较高的 HR 会缩短反应时间 (RT)。同时，OFC 和 dACC 中的一组神经元选择性地编码 HR 的逐次试验变化，与奖励值无关。杏仁核损伤后，HR 增加，并且 HR 和 RT 之间的关系发生改变。与这一变化同时发生的是，编码 HR 的 dACC 神经元比例有所增加。应用群体编码分析，我们发现，在双侧杏仁核损伤后，dACC 中的编码平衡在做出选择时偏离了向 HR 编码发出奖励值或选择方向的信号。总而言之，目前的结果提供了对额叶皮层如何发出身体唤醒和决策信号的深入了解。
How bodily arousal states influence decision-making has been a central question in psychology, but the neural mechanisms are unclear. We recorded heart rate (HR), a measure of bodily arousal, while simultaneously monitoring neural activity in orbitofrontal cortex (OFC) and dorsal anterior cingulate cortex (dACC) of macaques making reward-guided decisions. In intact macaques, higher HR was associated with shorter reaction times. Concurrently, the activity of a set of neurons in OFC and dACC selectively encoded HR. Following amygdala lesions, HR generally increased, and now the relationship between HR and reaction times was altered. At the neural level, the balance of encoding in dACC shifted toward signaling HR, suggesting a specific mechanism through which bodily arousal influences decision-making. Decision-making and representations of arousal are intimately linked. Behavioral investigations have classically shown that either too little or too much bodily arousal is detrimental to decision-making, indicating that there is an inverted “U” relationship between bodily arousal and performance. How these processes interact at the level of single neurons as well as the neural circuits involved are unclear. Here we recorded neural activity from orbitofrontal cortex (OFC) and dorsal anterior cingulate cortex (dACC) of macaque monkeys while they made reward-guided decisions. Heart rate (HR) was also recorded and used as a proxy for bodily arousal. Recordings were made both before and after subjects received excitotoxic lesions of the bilateral amygdala. In intact monkeys, higher HR facilitated reaction times (RTs). Concurrently, a set of neurons in OFC and dACC selectively encoded trial-by-trial variations in HR independent of reward value. After amygdala lesions, HR increased, and the relationship between HR and RTs was altered. Concurrent with this change, there was an increase in the proportion of dACC neurons encoding HR. Applying a population-coding analysis, we show that after bilateral amygdala lesions, the balance of encoding in dACC is skewed away from signaling either reward value or choice direction toward HR coding around the time that choices are made. Taken together, the present results provide insight into how bodily arousal and decision-making are signaled in frontal cortex.
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影响因子：
9.8
作者：
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通讯作者：
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DOI：
10.1073/pnas.1902297116
发表时间：
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影响因子：
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