SARS-CoV-2 Infection in Health Care Personnel and Their Household Contacts at a Tertiary Academic Medical Center: Protocol for a Longitudinal Cohort Study.
SARS-CoV-2 Infection in Health Care Personnel and Their Household Contacts at a Tertiary Academic Medical Center: Protocol for a Longitudinal Cohort Study.
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DOI：
10.2196/25410
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发表时间：
2021-04-30
影响因子：
1.7
通讯作者：
Aiello AE
中科院分区：
文献类型：
--
作者：
Ciccone EJ;Zivich PN;Lodge EK;Zhu D;Law E;Miller E;Taylor JL;Chung S;Xu J;Volfovsky A;Beatty C;Abernathy H;King E;Garrett HE;Markmann AJ;Rebuli ME;Sellers S;Weber DJ;Reyes R;Alavian N;Juliano JJ;Boyce RM;Aiello AE
卫生保健人员（HCP）暴露于SARS-CoV-2病毒的风险很高。虽然个人防护设备（PPE）可以减轻这种风险，但需要收集关于其使用情况和该人群中血清转化的其他风险因素的前瞻性数据。本研究的主要目的是（1）确定三级医疗中心HCP中SARS-CoV-2感染的发生率和风险因素，（2）主动监测PPE使用、研究参与者之间通过电子传感器的相互作用、家庭中的继发病例以及参与者的心理健康和幸福感。为了实现这些目标，我们在美国北卡罗来纳州的一个学术三级医疗中心设计了一项关于HCP及其家庭接触者中SARS-CoV-2感染的前瞻性观察性研究。入选的HCP完成了对症状和工作活动的频繁调查，并每2周提供一次血清和鼻腔样本用于SARS-CoV-2检测。此外，参与者之间的互动和他们在临床环境中的运动被智能手机应用程序和蓝牙传感器捕获。最后，每两周随机选择一部分参与者的家庭进行进一步调查，登记的家庭通过家庭收集套件提供血清和鼻腔样本。截至2020年12月31日，已招募211名HCP和53名家庭参与者。招募和后续工作正在进行中，预计将持续到2021年9月。关于HCP及其家庭接触者中SARS-CoV-2感染的风险，仍有许多需要了解的内容。通过使用多方面的前瞻性研究设计和特征良好的队列，我们将收集有关SARS-CoV-2在卫生保健环境中传播风险及其与社区联系的关键信息。DERR1-10.2196/25410
Health care personnel (HCP) are at high risk for exposure to the SARS-CoV-2 virus. While personal protective equipment (PPE) may mitigate this risk, prospective data collection on its use and other risk factors for seroconversion in this population is needed. The primary objectives of this study are to (1) determine the incidence of, and risk factors for, SARS-CoV-2 infection among HCP at a tertiary care medical center and (2) actively monitor PPE use, interactions between study participants via electronic sensors, secondary cases in households, and participant mental health and well-being. To achieve these objectives, we designed a prospective, observational study of SARS-CoV-2 infection among HCP and their household contacts at an academic tertiary care medical center in North Carolina, USA. Enrolled HCP completed frequent surveys on symptoms and work activities and provided serum and nasal samples for SARS-CoV-2 testing every 2 weeks. Additionally, interactions between participants and their movement within the clinical environment were captured with a smartphone app and Bluetooth sensors. Finally, a subset of participants’ households was randomly selected every 2 weeks for further investigation, and enrolled households provided serum and nasal samples via at-home collection kits. As of December 31, 2020, 211 HCP and 53 household participants have been enrolled. Recruitment and follow-up are ongoing and expected to continue through September 2021. Much remains to be learned regarding the risk of SARS-CoV-2 infection among HCP and their household contacts. Through the use of a multifaceted prospective study design and a well-characterized cohort, we will collect critical information regarding SARS-CoV-2 transmission risks in the health care setting and its linkage to the community. DERR1-10.2196/25410
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影响因子：
4.4
作者：
Malosh RE;Petrie JG;Callear AP;Monto AS;Martin ET
通讯作者：
Martin ET
影响因子：
2
作者：
Ainslie, Kylie E. C.;Haber, Michael J.;Monto, Arnold S.
通讯作者：
Monto, Arnold S.
影响因子：
13.8
作者：
Ioannou GN;Locke E;Green P;Berry K;O'Hare AM;Shah JA;Crothers K;Eastment MC;Dominitz JA;Fan VS
通讯作者：
Fan VS
影响因子：
3.7
作者：
Petrie JG;Ohmit SE;Cowling BJ;Johnson E;Cross RT;Malosh RE;Thompson MG;Monto AS
通讯作者：
Monto AS
影响因子：
3.7
作者：
Larios OE;Coleman BL;Drews SJ;Mazzulli T;Borgundvaag B;Green K;STOP-Flu Study Group;McGeer AJ
通讯作者：
McGeer AJ